Dose-response for occupational styrene exposures.

Details

• Personal Author:
  Bodell W ; Rappaport SM
• Description:
  The results of study concerning the dose/response relationship for occupational exposures to styrene were presented in this final performance report. A year long assessment of exposure to styrene (100425) was performed for a cohort of 48 workers in a fiberglass boat manufacturing facility. Assessment involved measuring styrene in air, exhaled air, and blood. Methods were developed for measuring adducts of styrene-7,8-oxide (96093) (SO) with proteins and with DNA in the blood. Estimates of the individual mean exposures to styrene ranged between 0.9 and 235mg/m3 for the 48 subjects, with an overall mean of 84.2mg/m3. There was a high degree of correlation between the estimated mean levels of styrene in the blood and exhaled air, and the exposure to styrene. There was also a significant correlation with sister chromatid exchanges (SCEs) and styrene exposure, even after controlling for cigarette smoke. The investigation optimized the analytical procedures for SO adducts with hemoglobin, serum albumin, and lymphocyte DNA. Statistically significant correlations were found between the mean exposure to styrene for each subject and the corresponding mean levels of several biomarkers. The authors note that this is the first example of a longitudinal investigation in which exposure to a genotoxic substance was measured along with a variety of biomarkers. The design of the study reduced measurement error in styrene exposure to an extent which allowed the authors to detect elevated levels of SCEs at styrene concentrations well below those which had been previously reported. The authors suggest that in the reinforced plastics industry styrene measurement in air is likely to be more efficient than that of biomarkers to determine the relationship between genotoxic effects and exposure to styrene. [Description provided by NIOSH]
• Subjects:
  DNA Hematologic Tests Occupational Exposure Occupational Health Plastics Polycyclic Aromatic Hydrocarbons Safety Ships
• Keywords:
  NIOSH-Grant; Grants-other; Biological-monitoring; Blood-analysis; Genotoxic-effects; DNA-damage; Dose-response; Occupational-exposure; DNA-adducts; Boat-manufacturing-industry; Reinforced-plastics; Aromatic-hydrocarbons
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  California ; North Carolina ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:00228744
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-002221, 1994 Apr; :1-9
• Contact Point Address:
  Biomedical & Environ Hlth Scis University of California School of Public Health Berkeley, CA 94720
• CAS Registry Number:
  Styrene (CAS RN 100-42-5) ; Styrene oxide (CAS RN 96-09-3)
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of California Berkeley
• Peer Reviewed:
  False
• Start Date:
  19850901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  19931227
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246316/cdc_246316_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]