Sister-chromatid exchanges, glutathione s-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers

Details

• Personal Author:
  Bechtold W ; Fajen, John M. ; Kelsey KT ; Ward J ; Wiencke JK
• Description:
  A study was conducted examining the genotoxicity of butadiene (106990) among occupationally exposed workers as well as a possible increased risk for individuals sensitive to diepoxybutane (298180) (DEB) and with deletion of the glutathione-S-transferase class theta gene (GSTT1). Baseline frequencies of lymphocytic sister chromatid exchanges (SCEs), DEB induced SCE frequencies, and GSTT1 deletion status were determined in 40 butadiene workers. The mean butadiene exposure levels during two analyses were found to be well below 1 part per million (ppm) and ranged from nondetectable to 8.53 ppm. Urinary butadiene metabolite 1,2-dihydroxy-4-(N-acetylcysteine-S-)- butane (M1) excretion did not correlate with butadiene exposure. Thirty four of the 40 workers studied were found to be resistant to SCE induction by DEB, whereas six were found to be sensitive. All DEB sensitive workers demonstrated deletion of GSTT1. No correlation was seen between the SCE frequency and exposure to butadiene or urinary M1 excretion. Only cigarette smoking and DEB sensitivity were significantly correlated with baseline SCE frequency. [Description provided by NIOSH]
• Subjects:
  Butadienes Chromosomes Energy Metabolism Genetics Hazardous Substances Occupational Exposure Occupational Health Safety Smokers Tobacco Products
• Keywords:
  Chromosome-damage Cigarette-smoking Genetic-factors Genotoxic-effects Grants-other Metabolites NIOSH-Author NIOSH-Grant NIOSH-Publication Occupational-exposure Toxic-effects

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• ISSN:
  0027-5107
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; New Mexico ; Ohio ; OSHA Region 1 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  267-273
• Volume:
  335
• Issue:
  3
• NIOSHTIC Number:
  nn:00230502
• Citation:
  Mutat Res 1995 Dec; 335(3):267-273
• Contact Point Address:
  Environmental Health Harvard School of Public Hlth 665 Huntington Avenue Boston, MA 02115
• CAS Registry Number:
  1,3-Butadiene (CAS RN 106-99-0) ; rel-(2R,2′R)-2,2′-Bioxirane (CAS RN 298-18-0)
• Federal Fiscal Year:
  1996
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19910930
• Source Full Name:
  Mutation Research
• End Date:
  19940929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ad99b4511c275723f3698122d0956382c6e37e8e866b7954c9c792feed8f5a9583ba28cc7f879daca442b19b329914858bac1b3ff6fe83f269f6d80989252935
• Download URL:
  https://stacks.cdc.gov/view/cdc/205610/cdc_205610_DS1.pdf
• File Type:
  [PDF - 598.39 KB ]