Pharmacological modulation of brain nicotinic binding sites

Details

• Personal Author:
  Costa LG
• Description:
  Information was summarized concerning nicotinic acetylcholine receptor modulation following repeated exposure to anticholinesterase compounds and nicotine (54115). Several studies have examined the effects of repeated nicotine administration on brain nicotinic receptors, particularly in an attempt to determine whether alteration of these sites would be important in developing tolerance to nicotine. Most investigators determined an increase in brain nicotine receptors. Repeated treatments with nicotinic agonist cytisin increased the acetylcholine binding in rat cerebral cortex, due to an increase in the density of nicotinic binding sites with no changes in affinity. The effect of prenatal nicotine exposure was most prominent during the second postnatal week and was most persistent in the cerebellum with only minor effects in the cerebral cortex. An important aspect of receptor modulation was the correlation of the observed biochemical alterations with changes in the behavioral effects of nicotine. The enhanced behavioral effect of nicotine after repeated exposure was linked to the observed increase in brain nicotinic cholinergic receptors. According to the author, knowledge concerning the in-vivo pharmacological regulation of brain nicotinic binding sites is still limited. Such binding sites are relevant to the mechanisms underlying tolerance and dependence to nicotine. [Description provided by NIOSH]
• Subjects:
  Enzymes Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Central-nervous-system Enzyme-activity Grants-other Nervous-system-disorders Neurotoxic-effects Neurotransmitters NIOSH-Grant NIOSH-Publication
• ISSN:
  1010-8793
• Publisher:
  Springer Berlin
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  299-316
• NIOSHTIC Number:
  nn:00214028
• Citation:
  Nicotinic acetylcholine receptors in the nervous system, NATO ASI Series. Clementi F, Gotti C, Sher E eds. Heidelberg, Germany: Springer Berlin 1988 Jan; 25:299-316
• Contact Point Address:
  Environmental Health University of Washington Dept of Environ Hlth, SC-34 Seattle, WA 98195
• CAS Registry Number:
  (-)-Nicotine (CAS RN 54-11-5)
• Editor(s):
  Clementi F; Gotti C; Sher E
• Federal Fiscal Year:
  1988
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other ; Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19860929
• Source Full Name:
  Nicotinic acetylcholine receptors in the nervous system, NATO ASI Series
• End Date:
  19900331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:268f0b8730b358c1df88c7ab9d6e7b09ff739b7e80cf9e24ebaf4b35d0de4898344d82eec763c499fa5270863dbe088539b007006f7214b927d8adaf69a81cfd
• Download URL:
  https://stacks.cdc.gov/view/cdc/205362/cdc_205362_DS1.pdf
• File Type:
  [PDF - 3.05 MB ]