Pharmacokinetics and metabolism of a single subneurotoxic oral dose of tri-o-cresyl phosphate in hens

Details

• Personal Author:
  Abou-Donia MB ; Suwita E
• Description:
  The disposition, metabolism, and pharmacokinetics of the plasticizer tri-o-cresyl-phosphate (78308) (TOCP) in plasma and some tissues of the hen were investigated. Laying hens were given a single oral dose of 50mg/kg carbon-14 labeled TOCP and sacrificed 0.5, 1, 2, or 5 days later. In plasma the half live of the carbon-14 labeled TOCP was 2 days. High performance liquid chromatography and liquid scintillation counting were used to analyze TOCP and its metabolites in the plasma, liver, kidneys, and lungs. Between 0.5 and 1 day after dosing, TOCP peaked in concentration in the plasma. Disappearance of TOCP from the plasma followed monoexponential kinetics with a half life of 2.2 days. At all time points there were appreciable concentrations of saligenin-cyclic-o-tolyl- phosphate in the plasma, the liver, kidneys, and lungs, registering half lives of 2.06, 1.36, 1.11, and 4.44, days in each sample type, respectively. The authors suggest that the presence of this active neurotoxic metabolite may contribute to the increased sensitivity of the hen over the rat to organophosphorus induced delayed neurotoxicity caused by TOCP exposure. [Description provided by NIOSH]
• Subjects:
  Laboratories Nervous System Nervous System Diseases Occupational Health Organophosphates Safety
• Keywords:
  Laboratory-animals Nervous-system-disorders Neurotoxic-effects NIOSH-Grant NIOSH-Publication Organo-phosphorus-compounds
• ISSN:
  0340-5761
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  237-241
• Volume:
  64
• Issue:
  3
• NIOSHTIC Number:
  nn:00197721
• Citation:
  Arch Toxicol 1990 Apr; 64(3):237-241
• Contact Point Address:
  Pharmacology Duke University Medical Center Box 3813 Durham, NC 27710
• CAS Registry Number:
  o-Cresyl phosphate (CAS RN 78-30-8)
• Federal Fiscal Year:
  1990
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Duke University, Durham, North Carolina
• Peer Reviewed:
  True
• Start Date:
  19840601
• Source Full Name:
  Archives of Toxicology
• End Date:
  19881031
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e1fe1896019328d502e3c22002cd02da094e9588cdb995bd98e8112fce9f83dcff9058a88b7de59ed83900803eb5475ca062bbb73547f6638db047e724680d46
• Download URL:
  https://stacks.cdc.gov/view/cdc/205360/cdc_205360_DS1.pdf
• File Type:
  [PDF - 503.64 KB ]