Old and new reflections on dioxin

Details

• Personal Author:
  Fingerhut, Marilyn A. ; Halperin, William E. ; Marlow, David A. ; Piacitelli, Laurie A. ; Steenland, Kyle ; Sweeney, Marie H. ; Fingerhut, Marilyn A. ; Halperin, William E. ; Marlow, David A. ; Piacitelli, Laurie A. ; Steenland, Kyle ; Sweeney, Marie H.
• Description:
  The authors of a 1978 NIOSH study on the effects of dioxin discussed portrayal of their results as a mixture of previous and inconsistent findings. The study included all 5172 chemical workers in the United States who had work records verifying assignment to the production of 2,4,5-trichlorophenoxyacetic-acid (93765) or its precursor 2,4,5- trichlorophenol (95954), both contaminated with 2,3,7,8- tetrachlorodibenzo-p-dioxin (1746016) (TCDD). A standard epidemiologic method was used but findings differed from those of other reports. A 15% overall excess of all cancers was found; this excess reached 46% in a subcohort having exposures over 1 year and latencies over 20 years. This group also exhibited a 42% excess of respiratory cancer and a nine fold excess of soft tissue sarcoma. Contributions of other occupational carcinogens or smoking were not ruled out; but, the authors conclude that their results indicate that TCDD is a carcinogen. [Description provided by NIOSH]
• Subjects:
  Dioxins Epidemiology Hydrocarbons Manufacturing And Industrial Facilities Mortality Neoplasms Occupational Exposure Occupational Health Safety
• Keywords:
  Cancer-rates Chemical-factory-workers Chlorinated-hydrocarbons Mortality-data NIOSH-Author Occupational-exposure
• ISSN:
  1044-3983
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  69-72
• Volume:
  3
• Issue:
  1
• NIOSHTIC Number:
  nn:00205379
• Citation:
  Epidemiology 1992 Jan; 3(1):69-72
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; 2,4,5-Trichlorophenol (CAS RN 95-95-4) ; Trichlorophenoxyacetic acid (CAS RN 93-76-5) ; 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; 2,4,5-Trichlorophenol (CAS RN 95-95-4) ; Trichlorophenoxyacetic acid (CAS RN 93-76-5)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  True
• Source Full Name:
  Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c5fc352e79e6a686cd7b8cfbe83877952869ebb3ae1d00bb31e0266657e55298619ef3188592fd19d43d7e62b8f4f069081a2c9d0897b203a5ed248cba4e98d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/205280/cdc_205280_DS1.pdf
• File Type:
  [PDF - 339.77 KB ]