Mutagenicity testing of selected industrial chemicals

Details

• Personal Author:
  Elliott J ; Golden CA ; Moon RG ; Ong T ; Taylor G
• Description:
  The mutagenic potentials of selected industrial chemicals and related compounds were evaluated. A total of 147 industrial chemicals and structurally related compounds were tested in the Ames/Salmonella assay using Salmonella-typhimurium strains (TA-98), (TA-100), (TA-1535), and (TA-1537) with or without metabolic activation by liver S9 mix from aroclor-1254 pretreated male Sprague- Dawley-rats. Five different concentrations of each chemical were used. The highest concentration was determined by the solubility and toxicity of the compound. A total of 120 compounds were not mutagenic, 23 were mutagenic to one or more of the strains, and four required metabolic activation. The authors conclude that a number of industrial chemicals have been found to be mutagenic in the Ames/Salmonella assay. These should be tested further in mammalian and submammalian systems. [Description provided by NIOSH]
• Subjects:
  Biological Assay Halothane Mutagens Nitrogen Compounds Occupational Health Platinum Safety
• Keywords:
  Bioassays Halogenated-hydrocarbons In-vitro-studies Microbial-test-systems Mutagenesis Nitro-compounds Organic-compounds Platinum-compounds
• Publisher:
  NCI; EPA; NIOSH
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  District of Columbia ; Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  470-493
• NIOSHTIC Number:
  nn:00204585
• Citation:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland. Kraybill HF, Blackwood IC, Freas NB, eds. Washington, DC: National Cancer Institute, Environmental Protection Agency, National Institute for Occupational Safety and Health, 1980 May; :470-493
• Editor(s):
  Kraybill HF; Blackwood IC; Freas NB
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:44c3d3d29944aa3c8fb84d5193ee5ffc3de6283f2f7ce1956d15466318ffa8f29c09e2d81c702f62c859aa11cb889067f10e2fa44695e051dd6c94e0d09b5868
• Download URL:
  https://stacks.cdc.gov/view/cdc/205166/cdc_205166_DS1.pdf
• File Type:
  [PDF - 533.85 KB ]