Mutagenicity testing of selected industrial chemicals.

Details

• Personal Author:
  Golden CA ; Moon RG
• Description:
  The mutagenicity of 147 industrial chemicals and structurally related compounds was studied in-vitro. The Ames Salmonella- typhimurium microsome plate incorporation test was used in the assay system with tester strains TA1535, TA1537, TA98, and TA100. Five different concentrations of each chemical were tested with and without S-9 prepared from the liver of Sprague-Dawley-rats pretreated with Aroclor-1254 (11097691). Of the 147 compounds tested, 120 were not mutagenic to any of the testers, either with or without metabolic activation. Metabolic activation was required for the mutagenic activity of 1,2,3-trichloropropane (96184), dimethoxyethylphthalate (131113), 2,4-dimethylaniline (95681), and 2,6-dinitrotoluene (606202). Twenty-three compounds were directly mutagenic to one or more testers. The direct mutagens included nitromethane (75525), 2-nitropropane (79469), methyl-bromide (74839), methylene-chloride (75092), monochloroethane (75003), 2,3- dinitrotoluene (602017), 2,5-dinitrotoluene (619158), 2,4,5- trinitrotoluene (610253), p-dinitrobenzene (100254), and m- dinitrobenzene (99650). [Description provided by NIOSH]
• Subjects:
  Biochemistry Biological Assay Hazardous Substances Mutagens Nitrogen Compounds Occupational Health Safety Toxicology
• Keywords:
  Bioassays Biochemical-tests Comparative-toxicology Hazardous-materials In-vitro-studies Mutagenesis Nitro-compounds
• Publisher:
  NCI; EPA; NIOSH
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  District of Columbia ; Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  470-493
• NIOSHTIC Number:
  nn:00123087
• Citation:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland. Kraybill HF, Blackwood IC, Freas NB, eds. Washington, DC: National Cancer Institute, Environmental Protection Agency, National Institute for Occupational Safety and Health, 1980 May; :470-493
• CAS Registry Number:
  1,2,3-Trichloropropane (CAS RN 96-18-4) ; 1,3-Dinitrobenzene (CAS RN 99-65-0) ; 1,4-Dinitrobenzene (CAS RN 100-25-4) ; 2,3-Dinitrotoluene (CAS RN 602-01-7) ; 2,4,5-Trinitrotoluene (CAS RN 610-25-3) ; 2,4-Dimethylaniline (CAS RN 95-68-1) ; 2,5-Dinitrotoluene (CAS RN 619-15-8) ; 2,6-Dinitrotoluene (CAS RN 606-20-2) ; 2-Nitropropane (CAS RN 79-46-9) ; Chloroethane (CAS RN 75-00-3) ; Dichloromethane (CAS RN 75-09-2) ; Dimethyl phthalate (CAS RN 131-11-3) ; Methyl bromide (CAS RN 74-83-9) ; Nitromethane (CAS RN 75-52-5) ; PCB-1254 (CAS RN 11097-69-1)
• Editor(s):
  Kraybill HF; Blackwood IC; Freas NB
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the first NCI/EPA/NIOSH collaborative workshop: progress on joint environmental and occupational cancer studies, May 6-8, 1980, Rockville, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7f9bb7891bfe03a6a7486ada622b79ff6dca398adf08d9c4d6ca6f407bbb912d6b9195edfaeeaf04da46221ba4417cb2185d1460e1917645d1a2e6d10918325f
• Download URL:
  https://stacks.cdc.gov/view/cdc/184554/cdc_184554_DS1.pdf
• File Type:
  [PDF - 533.83 KB ]