Liver disease associated with exposure to 1,1,1-trichloroethane

Details

• Personal Author:
  Heyl AE ; Hodgson, Michael J. ; Thiel DH
• Description:
  Cases of fatty liver disease (FLD) associated with occupational exposure to 1,1,1-trichloroethane (71556) (TCE) were described. Four males, 28, 27, 45, and 50 years old, who had complained of nausea, anorexia, chills, and fatigue were examined at an occupational medical clinic. All were diagnosed with FLD on the basis of a liver biopsy. The 45 year old patient had evidence of inactive cirrhosis. The 50 year old subject had active cirrhosis. None of the patients had any predisposing FLD factors such as excessive alcohol use, a history of receiving blood or blood products, or serological evidence of previous hepatitis-B or other viral infections. One patient denied any alcohol consumption. All four subjects had been occupational exposed to TCE. Estimated TCE exposures ranged up to 17718 parts per million. Two subjects reported minimal exposures to perchloroethylene (127184). The authors conclude that although the cases do not definitely establish a causal association they do raise the question of whether FLD can be associated with exposure to TCE. Since TCE has been shown to produce liver disease in laboratory animals and is associated with some degree of liver dysfunction in humans after substantial exposure and has not been shown to be safe, it should be regarded as potentially hepatotoxic to humans. [Description provided by NIOSH]
• Subjects:
  Case Reports Chlorine Compounds Hazardous Substances Liver Nervous System Occupational Exposure Occupational Health Safety Solvents
• Keywords:
  Case-studies Clinical-symptoms Liver-disorders Neurotoxic-effects NIOSH-Grant NIOSH-Publication Occupational-exposure Organic-solvents Organo-chlorine-compounds Toxic-effects
• ISSN:
  0003-9926
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  149
• Issue:
  8
• NIOSHTIC Number:
  nn:00190298
• Citation:
  Arch Intern Med 1989 Aug; 149(8):1793-1798
• Contact Point Address:
  Medicine University of Pittsburgh 149 Lothrop Hall Pittsburgh, PA 15261
• CAS Registry Number:
  1,1,1-Trichloroethane (CAS RN 71-55-6) ; Tetrachloroethylene (CAS RN 127-18-4)
• Federal Fiscal Year:
  1989
• NORA Priority Area:
  Neurotoxic Effects
• Performing Organization:
  University of Pittsburgh at Pittsburgh, Pittsburgh, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19870929
• Source Full Name:
  Archives of Internal Medicine
• End Date:
  19900928
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bb003147d2ee57cdc7b7255a172529e28b3b0405d588d95be8fa1d27b60a6ebc79e05f287fea40d31e8390a5707574d4a55e18bc19b8be961b3386a8656235b7
• Download URL:
  https://stacks.cdc.gov/view/cdc/205030/cdc_205030_DS1.pdf
• File Type:
  [PDF - 977.46 KB ]