NIOH and NIOSH basis for an occupational health standard; chlorobenzene
Published Date:January 1993
Corporate Authors:National Institute for Occupational Safety and Health ; Arbetsmiljöinstitutet (Sweden) ;
Industrial Safety/United States
Series:Arbete och hälsa ; 1992:31
DHHS publication ; no. (NIOSH) 93-102
Description:"Information relevant for assessing potential adverse health effects from occupational exposure to chlorobenzene (108907) was reviewed and summarized. Topics included physical properties, chemical properties, production levels, industrial uses, occupational exposure levels, toxicokinetics, acute and chronic toxicity, organ system toxicity, immunotoxicity, allergy, genotoxicity, carcinogenicity, teratogenicity, reproductive toxicity, dose/response relationships, and research needs. Studies have indicated that chlorobenzene is absorbed via respiratory and dermal routes and has resulted in headaches, dizziness, somnolence, and dyspeptic disorders in humans chronically exposed. There were no case reports or epidemiological studies available concerned with the potential carcinogenicity of chlorobenzene in humans. There was some limited evidence indicating that the compound is genotoxic and that it may induce hematopoietic toxicity at relatively moderate doses. Chlorobenzene was not classifiable as a human carcinogen. The author concludes that the central nervous system effects and the hepatotoxic effects should be considered in setting occupational exposure limits." - NIOSHTIC-2
"The contents of this document originally appeared in Arbete och halsa 1992:31, which was published in Solna, Sweden"--T.p. verso.
"This document was prepared by National Institute for Occupational Safety and Health, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia in cooperation with National Institute of Occupational Health, Solna, Sweden."
Includes bibliographical references (p. 69-77).
Supporting Files:No Additional Files
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