Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Details

• Personal Author:
  Andrews JS Jr. ; Fingerhut, Marilyn A. ; Halperin, William E. ; Marlow, David A. ; Needham LL ; Patterson DG Jr. ; Roberts, Daryl W. ; Sweeney, Marie H.
• Description:
  Nineteen subjects exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (2,3,7,8-TCDD), and who were previously found to have widely disparate levels of 2,3,7,8-TCDD in adipose tissue, were investigated to determine the cause of this phenomenon. The participants in the present study had previously demonstrated 2,3,7,8-TCDD levels ranging from 3.5 to 750 parts per trillion (ppt). Adipose tissue and serum samples were reanalyzed for 2,3,7,8- TCDD, and individual job history data was extracted from the original questionnaires. Employment records of the 19 participants were analyzed to evaluate exposure. Sixteen of the participants had worked at the same chemical factory; process records of the factory were analyzed to determine areas and periods of high exposure risk. Nine of the participants had worked in an area where 2,4,5- trichlorophenol (95954), hexachlorophene (70304), or 2,4,5- trichlorophenoxacetic-acid (93765) was produced. Three were truckers who had worked near 2,3,7,8-TCDD contaminated waste oils. Adipose tissue levels of 2,3,7,8-TCDD in the nine factory employees with exposure ranged from 41.9 to 750ppt, while those in the seven others ranged from 3.5 to 25.8ppt, a statistically significant difference. Levels in the three truckers ranged from 7.8 to 24.7ppt. Lipid adjusted serum levels demonstrated similar results. The authors conclude that stratification by exposure level explains the wide ranging levels of 2,3,7,8-TCDD in persons reporting occupational exposure to this compound. [Description provided by NIOSH]
• Subjects:
  Dioxins Environmental Exposure Hydrocarbons Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Phenol Safety Workplace
• Keywords:
  Adipose Tissue Author Keywords: Dioxin Benzofurans Chemical-industry-workers Chlorinated-hydrocarbons Dibenzofurans Environmental-exposure NIOSH-Author Occupational-exposure PCDBs Phenols Production Workers Serum Work-areas

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Missouri ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  135-146
• Volume:
  16
• Issue:
  2
• NIOSHTIC Number:
  nn:00190086
• Citation:
  Am J Ind Med 1989 Feb; 16(2):135-146
• Contact Point Address:
  Dr. Patterson, Centers for Disease Control, Chamblee 17/1814, F17, 1600 Clifton Road, NE Atlanta, CA 30333
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; 2,4,5-Trichlorophenol (CAS RN 95-95-4) ; Hexachlorophene (CAS RN 70-30-4) ; Trichlorophenoxyacetic acid (CAS RN 93-76-5)
• Federal Fiscal Year:
  1989
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:20efd876bffac6db298c641d41c49c314fa817ce3ca8d3b43b6cc26c42a60d22786e76695c126d7c42abe9565b72e79357e6c1a49dba9f54cfb928a90873cf49
• Download URL:
  https://stacks.cdc.gov/view/cdc/205026/cdc_205026_DS1.pdf
• File Type:
  [PDF - 655.07 KB ]