A retrospective job exposure matrix for estimating exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Details

• Personal Author:
  Fingerhut, Marilyn A. ; Marlow D ; Piacitelli, Laurie A. ; Steenland, Kyle ; Sweeney M
• Description:
  A job exposure matrix was developed to estimate cumulative 2,3, 7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure for a subcohort of 3,538 workers at 8 of the 12 U.S. plants that produced 2,4,5-trichlorophenol or one of it's derivatives between 1942 to 1984. These exposure estimates will be used in exposure-response analyses in an update of a 1991 NIOSH cohort mortality study. The exposure matrix was developed to account for job, plant, and era dependent differences in TCDD exposure. The TCDD exposure estimates are based on (1) the concentration of TCDD in micrograms per gram present in process materials; (2) the duration of exposure to TCDD contamination, expressed as a fraction of a work day; and (3) a qualitative contact factor (0.05-1.5) to account for the extent of worker contact with the TCDD contaminated material. These three factors are multiplied together to yield a daily TCDD exposure score. The sum of the daily exposure scores constituted an individual's cumulative exposure score. Daily TCDD exposure scores range from 0.001 to 1250. Cumulative TCDD exposure scores are distributed from 0.002 to 1,651,611 exposure score days. The TCDD cumulative exposure score, which incorporates both duration and level of exposure, provides a means for ranking workers for evaluating the relationship between TCDD exposure and mortality in a retrospective cohort study analysis. [Description provided by NIOSH]
• Subjects:
  Dioxins Environmental Exposure Environmental Monitoring Environmental Pollution Hydrocarbons Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Polychlorinated Biphenyls Safety Workplace

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• Keywords:
  Chemical-industry-workers Chemical-manufacturing-industry Chlorinated-dioxins Chlorinated-hydrocarbons Chlorinated-phenols Dose-response Employee-exposure Environmental-contamination Exposure-assessment Humans Industrial-exposures Job-analysis Workplace-studies

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• Publisher:
  American Industrial Hygiene Association
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  District of Columbia ; Georgia ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division ; OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  74
• NIOSHTIC Number:
  nn:20044033
• Citation:
  American Industrial Hygiene Conference and Exposition, May 9-15, 1998, Atlanta, Georgia. Fairfax, VA: American Industrial Hygiene Association, 1998 May; :74
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; 2,4,5-Trichlorophenol (CAS RN 95-95-4)
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  False
• Source Full Name:
  American Industrial Hygiene Conference and Exposition, May 9-15, 1998, Atlanta, Georgia
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4fa00a7989f8b1a7ce1751c04960cfb254b210c0a0c50ad167381359bd78a611e8f56afef5aa4d88e466add75767d51b59ff4eca6a17d3e4488e20e32805043d
• Download URL:
  https://stacks.cdc.gov/view/cdc/199887/cdc_199887_DS1.pdf
• File Type:
  [PDF - 633.68 KB ]