Is the antioxidant butylated hydroxytoluene a depigmenting agent in man

Details

• Personal Author:
  Gellin G ; Maibach HI ; Ring M
• Description:
  The depigmenting potential of butylated-hydroxytoluene (128370) (BHT) was studied in humans. The study group consisted of 16 healthy, darkly pigmented male volunteers. They were given occlusion patches containing 0, 0.2, 0.5, 1.0, or 3.3 percent BHT in water washable cream or 0.5 percent dilaurylthiodipropionate (123284), 4-hydroxymethyl-2,6-di-tert-butylphenol, or 4,4'- methylinebis(2,6-di-tert-butylphenol) daily for 60 days. The application sites were examined weekly during the study period and at monthly intervals for 2 months afterwards. Irritation was seen at some of the test sites. No evidence of depigmentation was seen with BHT or any of the other compounds. The authors conclude that BHT does not cause depigmentation when applied as occlusion patches to human volunteers. Since the test protocol used is extremely rigorous, the negative result suggests that BHT does not have a depigmenting potential in humans. They note that BHT is currently being tested in pigmented-guinea-pigs in an effort to develop an animal model that is relevant to humans. [Description provided by NIOSH]
• Subjects:
  Antioxidants Dermatitis Laboratories Occupational Health Safety Skin Skin Diseases
• Keywords:
  Laboratory-techniques Laboratory-testing NIOSH-Grant NIOSH-Publication Skin-disorders Skin-tests
• ISSN:
  0105-1873
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  295-296
• Volume:
  1
• Issue:
  5
• NIOSHTIC Number:
  nn:00186818
• Citation:
  Contact Dermatitis 1975 Oct; 1(5):295-296
• Contact Point Address:
  Dermatology University of California Department of Dermatology San Francisco, Calif 94122
• CAS Registry Number:
  2,6-Di-tert-butyl-4-methylphenol (CAS RN 128-37-0) ; Dilauryl thiodipropionate (CAS RN 123-28-4)
• Federal Fiscal Year:
  1976
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  True
• Start Date:
  19740501
• Source Full Name:
  Contact Dermatitis
• End Date:
  19780430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3fd9fcaf3c20ca6d829d4d41a42f76b36f506865af6747ef7274625f9afd44eeaa5be45f7cd0f1e5c7316641a2317971d5d34d961a6cdde74c63f04975aaae62
• Download URL:
  https://stacks.cdc.gov/view/cdc/204988/cdc_204988_DS1.pdf
• File Type:
  [PDF - 159.65 KB ]