Percutaneous absorption of hydroquinone in humans: effect of 1-dodecylazacycloheptan-2-one (Azone) and the 2-ethylhexyl ester of 4-(dimethylamino) benzoic acid (Escalol 507).

Details

• Personal Author:
  Bucks DA ; Maibach RH ; McMaster JR
• Description:
  The effects of a penetration enhancer, 1-dodecylazacycloheptan-2-one (Azone) and a sunscreen, the 2-ethylhexyl ester of 4-(dimethylamino)- benzoic-acid (Escalol 507) on the percutaneous absorption of hydroquinone (123319) were studied. Volunteers each received a single 100 microliter dose of carbon-14 labeled hydroquinone module by topical application to forehead skin. Module 1 contained Azone and Escalol-507, module 2 contained Azone, module 3 contained Escalol-507 and module 4 contained no Azone or Escalol-507. Average percutaneous absorption of hydroquinone as estimated from the urinary elimination data was 35, 66, 26, and 57 percent for modules 1, 2, 3, and 4, respectively. Peak elimination was noted within the first 12 hours and elimination was complete within 5 days from application. Escalol-507 (3 percent by weight) significantly inhibited the absorption. Azone (0.5 percent by weight) did not significantly increase absorption either alone or with Escalol-507 present. The authors suggest that if Azone were used at higher concentrations or in a different vehicle system, the findings might be different. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Antioxidants Biopharmaceutics Dermatitis Occupational Health Safety Skin Skin Absorption
• Keywords:
  NIOSH-Grant; Dermatitis; Skin-exposure; Skin-absorption; Antioxidants; Pharmaceuticals; Humans
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-20
• NIOSHTIC Number:
  nn:00182770
• NTIS Accession Number:
  PB89129985
• Citation:
  Departments of Dermatology and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California, 1987 Dec; :1-20
• Contact Point Address:
  Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
• CAS Registry Number:
  Hydroquinone (CAS RN 123-31-9)
• Federal Fiscal Year:
  1988
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  False
• Start Date:
  19840928
• Source Full Name:
  Departments of Dermatology and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California
• End Date:
  19871231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246166/cdc_246166_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]