Intrapulmonary deposition and retention modeling of chrysotile asbestos fibers in rats

Details

• Personal Author:
  Asgharian B ; Pinkerton KE ; Yu CP
• Description:
  A theoretical model was presented to simulate the deposition and clearance processes of chrysotile (12001295) asbestos fibers in an asymmetric lung in order to explain the observed nonuniformity. The lung burdens of fibers of different size ranges in each alveolar region of the rat lung were calculated for an exposure condition of 7 hours a day, 5 days a week for a 12 month period. Regions with fewer airway generations in their path had a higher value of fiber retention and a longer mean length. The smaller fiber accumulation in the region with high airway generation number was attributed to the greater loss by deposition along the airway path. The authors note that because deposition of fibers occurs mostly at airway bifurcations, an airway path ending at a higher airway generation number would have a larger deposition loss. Since long fibers have a higher deposition efficiency at the bifurcation than the short ones, a smaller fraction of long fibers will reach the alveolar space. The mean fiber length in a region of higher generation number will therefore be smaller. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Asbestos Inorganic Chemicals Laboratories Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Airborne-fibers Alveolar-cells Asbestos-fibers Body-burden In-vivo-study Inhalation-studies Laboratory-animals Lung-irritants Respiratory-system-disorders Tissue-distribution
• ISSN:
  0021-8502
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  6
• NIOSHTIC Number:
  nn:00204038
• Citation:
  J Aerosol Sci 1991 Jan; 22(6):757-763
• Federal Fiscal Year:
  1991
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  19900930
• Source Full Name:
  Journal of Aerosol Science
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4c875787cb55673dfff88b3ed49ca784241df6291c677ead3319acf114baec756c54aa35cbf1082f5b0a6dc28a3767a8b1d65d1a516c65359506a30c446c492c
• Download URL:
  https://stacks.cdc.gov/view/cdc/204975/cdc_204975_DS1.pdf
• File Type:
  [PDF - 433.65 KB ]