Cellular and Molecular Mechanisms of Asbestosis

Details

• Personal Author:
  Cutroneo K ; Doherty J ; Gilbert R ; Marsh J ; Mossman BT ; Shatos MA
• Description:
  Occupational and experimental exposure to asbestos is associated with the development of peribronchiolar and interstitial pulmonary fibrosis. Like other asbestosassociated diseases of the respiratory tract (ie, mesothelioma and bronchogenic carcinoma), asbestosis appears to involve alterations in differentiation and proliferation of affected cell types. Whether the disease process involves either an increase in replication of fibroblasts in the lung or an enhanced ability of individual fibroblasts to produce more collagen or both is uncertain. To address this question, we used a combination of in vitro and in vivo approaches. [Description provided by NIOSH]
• Subjects:
  Animals Asbestos Cells, Cultured Cytotoxins Inorganic Chemicals Laboratories Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety

  More +
• Keywords:
  Animal-studies Asbestos-fibers Asbestosis Cell-cultures Cell-damage Cytotoxic-effects In-vitro-studies In-vivo-study Laboratory-animals Lung-cells Respiratory-system-disorders

  More +
• ISSN:
  0012-3692
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 1 ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  89
• Issue:
  3
• NIOSHTIC Number:
  nn:20037423
• Citation:
  Chest 1986 Mar; 89(3)(Suppl):160S-161S
• Federal Fiscal Year:
  1986
• Performing Organization:
  University of Vermont & St Agric College, Burlington, Vermont
• Peer Reviewed:
  True
• Start Date:
  19840928
• Source Full Name:
  Chest
• Supplement:
  Suppl
• End Date:
  19870831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:85a97b4e62b23a47bd76e1294c608de9b05b760da962d3273b42cff77ea709233522e6cdd2cbb65422116dc2b6f1e883db6e8f6d370635c37b3513dee95a959a
• Download URL:
  https://stacks.cdc.gov/view/cdc/188521/cdc_188521_DS1.pdf
• File Type:
  [PDF - 292.52 KB ]