Information profiles on potential occupational hazards: inorganic azides

Details

• Description:
  Information was presented for the following inorganic azides: barium- azide (18810587), cesium-azide (22750578), hydrazoic-acid (7782798), lead-azide (13424469), lithium-azide (19597694), potassium-azide (20762601), rubidium-azide (22756361), silver-azide (13863882), and sodium-azide (26628228). The data given for each compound included chemical structure, synonyms, chemical and physical properties, production information, uses, manufacturers and distributors, manufacturing processes, impurities and additives, occupational exposures, control technology and work practices, biological effects, ongoing studies, exposure standards, and sources of additional information. While there did not appear to be a lot of research available on toxicity of inorganic azides what findings there were suggested that toxic effects are due to the azoimide radical. The major acute effects of toxic doses of either sodium- azide or hydrazoic-acid to animals included hypotension, respiratory stimulation and convulsions, followed by respiratory depression and death. Humans who have suffered accidental exposures experienced inflammation of the mucous membranes and eye irritation. Necrosis and demyelination of nerve fibers were reported among mice and monkeys following acute intraperitoneal and subchronic intramuscular exposures, respectively. Subchronic oral exposure to rats caused histologic cerebral and liver damage. Mutagenicity testing was positive for sodium-azide in a variety of assays. [Description provided by NIOSH]
• Subjects:
  Agriculture Hazardous Substances Insecticides Irritants Metals Mutagens Nervous System Nervous System Diseases Occupational Exposure Occupational Health Safety

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• Keywords:
  Agricultural-chemicals Brain-damage Nervous-system-disorders Occupational-exposure Organo-metallic-compounds Pesticides Preservatives Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-54
• NIOSHTIC Number:
  nn:00188266
• NTIS Accession Number:
  PB89-215834
• Citation:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-608, Second Draft 1981 Oct; :1-54
• CAS Registry Number:
  Barium azide (Ba(N3)2) (CAS RN 18810-58-7) ; Cesium azide (CAS RN 22750-57-8) ; Hydrazoic acid (CAS RN 7782-79-8) ; Lead azide (Pb(N3)2) (CAS RN 13424-46-9) ; Lithium azide (CAS RN 19597-69-4) ; Potassium azide (CAS RN 20762-60-1) ; Rubidium azide (Rb(N3)) (CAS RN 22756-36-1) ; Silver azide (CAS RN 13863-88-2) ; Sodium azide (CAS RN 26628-22-8)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-608, Second Draft
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0a08f382ee7421f0adbf651b9dcdc9f8b702086eb5f648d1132115400f86e2137513fb7d88155e1f11caf7d8f50eb68fb884473e9b4304609ac997712f1e11eb
• Download URL:
  https://stacks.cdc.gov/view/cdc/204943/cdc_204943_DS1.pdf
• File Type:
  [PDF - 1.55 MB ]