Information profiles on potential occupational hazards: xylenols.

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Information was provided on all six isomers of xylenol, including chemical structure, biological activity, production, manufacturers, uses, synonyms, chemical and physical properties, distributors, manufacturing processes, control technology, work practices, impurities, occupational exposures, ongoing studies, and sources of additional information. The isomers discussed included 2,3-xylenol (526750), 2,4-xylenol (105679), 2,5-xylenol (95874), 2,6-xylenol (576261), 3,4-xylenol (95658), and 3,5-xylenol (108689). The xylenols were all moderately toxic with medial lethal toxicity doses ranging between 383 to 980mg/kg for mice and 296 to 3200mg/kg for rats. Acute oral poisoning caused dyspnea, disturbance of motor coordination, colonic spasms, and paralysis. Mucous membranes were irritated and respiratory activity affected through inhalation exposure. They were rapidly absorbed through the skin, causing minor skin irritation. Minor effects were manifested on the central nervous system as well as minor tissue damage to the liver, spleen, and kidney. The levels of sulfhydryl groups in the blood and internal organs of exposed animals were all affected by xylenol exposure. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Agriculture Hazardous Substances Irritants Lubricants Nervous System Diseases Occupational Exposure Occupational Health Safety Solvents
• Keywords:
  NIOSH-Contract; Contract-210-79-0030; Agricultural-chemicals; Lubricants; Organic-solvents; Toxic-effects; Occupational-exposure; Respiratory-irritants; Nervous-system-disorders
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-53
• NIOSHTIC Number:
  nn:00188267
• NTIS Accession Number:
  PB89215677
• Citation:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-527, Second Draft 1981 Mar; :1-53
• CAS Registry Number:
  2,3-Dimethylphenol (CAS RN 526-75-0) ; 2,4-Dimethylphenol (CAS RN 105-67-9) ; 2,5-Dimethylphenol (CAS RN 95-87-4) ; 2,6-Dimethylphenol (CAS RN 576-26-1) ; 3,4-Dimethylphenol (CAS RN 95-65-8) ; 3,5-Dimethylphenol (CAS RN 108-68-9)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Source Full Name:
  Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-527, Second Draft
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242811/cdc_242811_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]