Induction of neonatal rat skin and liver aryl hydrocarbon hydroxylase by coal tar and its constituents

Details

• Personal Author:
  Bickers DR ; Dutta-Choudhury T ; Mukhtar H ; Wroblewski D
• Description:
  The effects of coal-tar (8007452) and selected, defined, purified constituents of therapeutic coal tar on skin and liver aryl- hydrocarbon-hydroxylase (AHH) activity of neonatal rats were investigated. Application of coal-tar solution to neonatal rats 24 hours prior to sacrifice induced skin and liver AHH 15 and eight fold respectively. AHH induction in isolated epidermis and dermis was ten and 18 fold over the corresponding control values. Application of coal-tar to the skin of pregnant rats resulted in induction of skin and liver AHH activity in both mothers and prenatal rats. Coal-tar fumes induced skin and liver enzyme activities in the control animals housed adjacent to the exposed animals, but to a significantly less extent. Among the several defined constituents of coal-tar were some with measurable induction effects including benzo(a)pyrene (50328) (BP), anthracene (120127) and acridine (260946). These findings suggested that for therapeutic purposes it would be desirable to remove those constituents of coal-tar with potentially toxic and/or carcinogenic effects such as BP. Ideally these could be selectively extracted while maintaining the therapeutic efficacy of the coal tar. [Description provided by NIOSH]
• Subjects:
  Carcinogens Dermatitis Digestive System Enzymes Hydrocarbons Laboratories Liver Occupational Health Polycyclic Aromatic Hydrocarbons Safety Skin Skin Absorption

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• Keywords:
  Enzyme-activity Laboratory-animals Liver-enzymes NIOSH-Grant NIOSH-Publication Polycyclic-aromatic-hydrocarbons Skin-absorption Skin-exposure Therapeutic-agents
• ISSN:
  0022-202X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  227-229
• Volume:
  78
• Issue:
  3
• NIOSHTIC Number:
  nn:00187023
• Citation:
  J Invest Dermatol 1982 Mar; 78(3):227-229
• Contact Point Address:
  Medicine Cleveland V a Hospital 10701 East Blvd Cleveland, Ohio 44106
• CAS Registry Number:
  Acridine (CAS RN 260-94-6) ; Anthracene (CAS RN 120-12-7) ; Benzo[a]pyrene (CAS RN 50-32-8) ; Coal tar (CAS RN 8007-45-2)
• Federal Fiscal Year:
  1982
• Performing Organization:
  Case Western Reserve University, Cleveland, Ohio
• Peer Reviewed:
  True
• Start Date:
  19800929
• Source Full Name:
  Journal of Investigative Dermatology
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5f129d9fa91606126c3635d45a3e4fbf1e234a382cdb5b9a1e68fe8e0b4d2f65eef3c0dbc7119a1f56e00e44763f66f7d7535293ad5a45dead42e9e340a18262
• Download URL:
  https://stacks.cdc.gov/view/cdc/204922/cdc_204922_DS1.pdf
• File Type:
  [PDF - 1.59 MB ]