Evidence that coal tar is a mixed inducer of microsomal drug-metabolizing enzymes

Details

• Personal Author:
  Bickers DR ; Mukhtar H
• Description:
  The effect of coal-tar (8007452) on microsomal drug metabolizing enzymes was investigated in neonatal rats. Four day old rats were treated topically with 100 microliters of coal-tar, or 3- methylcholanthrene or Aroclor-1254 for comparison. Exposure to coal- tar resulted in the induction of hepatic cytosolic glutathione-S- transferase and microsomal epoxide-hydrolase and aminopyrine-N- demethylase activities. Treatment with coal-tar resulted in a 1 nanometer shift to the blue region in the wavelength maximum of the hepatic microsomal hemoprotein cytochrome-P-450, a result which was analogous to the effect of the polychlorinated biphenyl Aroclor- 1254. The authors conclude from these findings that therapeutic coal-tar contains both type-I and type-II inducers of hepatic drug metabolizing enzymes. The findings do not indicate that the responses observed are due to a single constituent or to multiple constituents of coal-tar inasmuch as the response may be due wholly or in part to unidentified factor(s) acting alone or in combination. It is also likely that the observed response of drug metabolizing enzyme activities to coal-tar may be the result of synergism between several constituents whose individual concentrations may be insufficient to induce the observed responses. [Description provided by NIOSH]
• Subjects:
  Dermatitis Digestive System Enzymes Hydrocarbons Laboratories Liver Occupational Health Safety Skin
• Keywords:
  Enzyme-activity Laboratory-animals Liver-enzymes NIOSH-Grant NIOSH-Publication Skin-exposure
• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  221-227
• Volume:
  11
• Issue:
  3
• NIOSHTIC Number:
  nn:00187035
• Citation:
  Toxicol Lett 1982 May; 11(3-4):221-227
• Contact Point Address:
  Medicine Cleveland V a Hospital 10701 East Blvd Cleveland, Ohio 44106
• CAS Registry Number:
  Coal tar (CAS RN 8007-45-2)
• Federal Fiscal Year:
  1982
• Performing Organization:
  Case Western Reserve University, Cleveland, Ohio
• Peer Reviewed:
  True
• Start Date:
  19800929
• Source Full Name:
  Toxicology Letters
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:059cfc233b132debf7366b099b5be9acb733d9f56fb2c6575d23b7a5c8a8357919dcdeff7d068b99d383cdae0fafdb2afb6cc8cad76939132f039354bd8508b8
• Download URL:
  https://stacks.cdc.gov/view/cdc/204711/cdc_204711_DS1.pdf
• File Type:
  [PDF - 516.64 KB ]