Evaluation of porphyria cutanea tarda in U.S. workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Details

• Personal Author:
  Calvert, Geoffrey M. ; Fingerhut, Marilyn A. ; Halperin, William E. ; Hornung, Richard W. ; Sweeney, Marie H.
• Description:
  The association between occupational exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin (1746016) (TCDD) contaminated chemicals and porphyria cutanea tarda, uroporphyrinuria, and coproporphyrinuria was examined in 281 former chemical workers. An unexposed comparison group of 260 age, race, and sex matched individuals was recruited from the neighborhoods where the workers lived. The study cohort members had been employed more than 15 years earlier in the manufacture of sodium-trichlorophenol (136323), 2,4,5-trichlorophenoxyacetic-ester, or hexachlorophene (70304). The workers had a statistically significantly elevated mean serum TCDD level of 220 picograms/gram of lipid compared to a mean level of 7 picograms/gram of lipid in the comparison group. None of the participants demonstrated symptomatic porphyria cutanea tarda. Subclinical porphyria cutanea tarda was found in three workers and three comparisons. Urinary uroporphyrin and urinary coproporphyrin levels showed no statistically significant differences between the workers and the comparisons. Logistic regression analysis failed to show a significant association between the risk of range urinary uroporphyrin or coproporphyrin levels and any measure of TCDD exposure. The authors conclude that there was not sufficient evidence to convincingly support or refute an association between TCDD exposure and porphyria cutanea tarda or porphyrinuria. [Description provided by NIOSH]
• Subjects:
  Agriculture Dioxins Energy Metabolism Herbicides Hydrocarbons Manufacturing And Industrial Facilities Occupational Health Porphyrins Safety Skin Diseases Urine

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• Keywords:
  Agricultural-chemicals Chemical-industry-workers Chemical-manufacturing-industry Chlorinated-hydrocarbons Metabolic-study NIOSH-Author Skin-disorders Urinalysis
• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  4
• NIOSHTIC Number:
  nn:00219021
• Citation:
  Am J Ind Med 1994 Apr; 25(4):559-571
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; Hexachlorophene (CAS RN 70-30-4) ; Sodium 2,4,5-trichlorophenolate (CAS RN 136-32-3)
• Federal Fiscal Year:
  1994
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:28dfa79bd9227eb3a2a2acd983da3de0d94dccec9a3a0a223b66bfc0f364613b9429e1afcc83381c731e4dca563a1fec5f5a8ba5421b1c7c9481f9f640d8baa8
• Download URL:
  https://stacks.cdc.gov/view/cdc/204688/cdc_204688_DS1.pdf
• File Type:
  [PDF - 846.66 KB ]