Mutagenicity studies of dioxin and related compounds with the Salmonella arabinose resistant assay system.

Details

• Personal Author:
  Nath J ; Ong T ; Soler-Niedziela L ; Zeiger E
• Description:
  Mutagenicity tests were performed for components of the defoliant Agent-Orange with the Salmonella arabinose resistant assay system. These components included 2,4-dichlorophenoxyacetic-acid (94757) (2,4-D) and 2,4,5-trichlorophenoxyacetic-acid (93765) (2,4,5-T) along with butyl, isobutyl and isooctyl esters and the contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD). Arabinose sensitive S-typhimurium-strain-SV50 was used as the tester strain. Rat and hamster liver S9 homogenate and S9 mix were used for metabolic activation. No mutagenic response to the test compounds was observed under any of the assay conditions used. With the use of activation, neither hamster nor rat S9 induced any mutagenic response. It seems likely that the compounds tested do not cause point mutations. Even without doubling no dose responses were noted in any of the study compounds. In all compounds, except for TCDD, variable toxicity was evident at the higher dose levels of 3333 and 10000 micrograms/plate. [Description provided by NIOSH]
• Subjects:
  Agriculture Biological Assay Herbicides Hydrocarbons Mutagens Occupational Health Safety
• Keywords:
  Agricultural-chemicals Bioassays Chlorinated-dioxins Chlorinated-hydrocarbons Microbial-test-systems
• ISSN:
  0884-8181
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  137-145
• Volume:
  3
• Issue:
  2
• NIOSHTIC Number:
  nn:00180887
• Citation:
  Toxic Assess 1988 Mar; 3(2):137-145
• CAS Registry Number:
  (2,4-Dichlorophenoxy)acetic acid (CAS RN 94-75-7) ; 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; Trichlorophenoxyacetic acid (CAS RN 93-76-5)
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  True
• Source Full Name:
  Toxicity Assessment
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:458bec5cc34581a697cee5a85261009419e655b5df03833aa4e4d74358cb3e7f2b6bfd12f3470e99b22ba389644f1236360b9b02f973ad34122f22a7d0238fd6
• Download URL:
  https://stacks.cdc.gov/view/cdc/185566/cdc_185566_DS1.pdf
• File Type:
  [PDF - 420.09 KB ]