A Retrospective Job Exposure Matrix for Estimating Exposure to 2,3, 7,8-Tetrachlorodibenzo-P-Dioxin

Details

• Personal Author:
  Fingerhut, Marilyn A. ; Marlow D ; Piacitelli, Laurie A. ; Steenland, Kyle ; Sweeney, Marie H.
• Description:
  A job exposure matrix was developed to estimate the 2,3, 7,8-tetrachlorodibenzo-p-dioxin exposure of 3,538 workers who produced 2,4,5-trichlorophenol and its derivatives. Daily TCDD exposure scores that were plant, process, and period specific were estimated for each job title as the product of 1) the concentration of TCDD (microg/g); 2) a qualitative factor to account for the extent of worker contact and 3) time exposed to TCDD contamination. Daily scores were summed to compute individual cumulative TCDD exposure scores. Daily TCDD exposure scores ranged from 0.001 to 1,250. Cumulative TCDD scores ranged from 0.002 to 1,559,430. The 393 workers with records of chloracne in the TCDD exposure cohort (11%) had markedly higher cumulative scores than those with no record of chloracne (a median score of 11,546 vs. 77). The cumulative TCDD exposure scores incorporate both duration and level of exposure, and permit the relative ranking of worker exposures for the evaluation of exposure-response relationships between TCDD exposure and mortality in an updated cohort study analysis. [Description provided by NIOSH]
• Subjects:
  Dioxins Environmental Pollution Manufacturing And Industrial Facilities Occupational Health Risk Assessment Safety Skin Skin Diseases Workplace
• Keywords:
  2,4,5-trichlorophenol Agent Orange Author Keywords: Dioxin Chemical Industry Workers Chemical Manufacturing Industry Chlorinated Hydrocarbons Dose Response Environmental Contamination Exposure Assessment Humans Phenoxy Herbicides Risk Analysis Skin Disorders Skin Lesions TCDD Workplace Studies

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  District of Columbia ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division ; OD - Office of the Director ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  28-39
• Volume:
  38
• Issue:
  1
• NIOSHTIC Number:
  nn:20020782
• Citation:
  Am J Ind Med 2000 Jul; 38(1):28-39
• Contact Point Address:
  Laurie Piacitelli, NIOSH, 4676 Columbia Parkway, MS R14, Cincinnati, OH 45226
• Email:
  lap1@cdc.gov
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6) ; 2,4,5-Trichlorophenol (CAS RN 95-95-4)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b9e1333165a998b900d3f2488c9c80236169427da4593a4530e0e09ad098fe860691191c7daeec8f62e50703ddb6c6228f2b745f4d20a5e93bd7718dbecfa370
• Download URL:
  https://stacks.cdc.gov/view/cdc/198448/cdc_198448_DS1.pdf
• File Type:
  [PDF - 141.57 KB ]