Enhancing effect of tetrandrine on sister-chromatid exchanges induced by mitomycin C and cigarette-smoke condensate in mammalian cells

Details

• Personal Author:
  Ong T ; Whong Z ; Wu L ; Xing G
• Description:
  The effect of tetrandrine (518343) (TD) on enhancing the actions of the mutagens mitomycin-C (50077) (MMC) and cigarette smoke condensate (CSC) were examined. Chinese-hamster cell lines were exposed for 3 hours to: 20 microliters CSC; 40 or 80 micrograms/milliliter (microg/ml) TD; or 20, 40, or 80 microliters TD plus 20 microliters CSC without S9 activation. The cells were also exposed to 0.01microg/ml MMC; 40 or 80microg/ml TD; or 20, 40, or 80microg/ml TD plus 0.01microg/ml MMC. SCE scores of the individual compounds were compared with those of the combined treatments. CSC and MMC caused an increase in the frequency of SCEs, as did 80microg/ml TD after metabolic activation of the cells. Compared to the sum of the effects of CSC and TD alone, the combined effect of CSC plus 40microg/ml or more TD showed a 50% increase in SCEs. A similar enhancing effect was seen for MMC plus TD. The authors conclude that TD is an effective enhancer of the genotoxic actions of MMC and CSC. [Description provided by NIOSH]
• Subjects:
  Antineoplastic Agents Chromosomes Laboratories Mutagens Occupational Health Safety Smokers Tobacco Products
• Keywords:
  Antineoplastic-agents Author Keywords: Tetrandrine Chromosome-damage Cigarette-smoke Condensate Cigarette-smoking Genotoxic-effects In-vitro-study Laboratory-animals Mammalian-cells Mitomycin C Mutagenicity NIOSH-Author Pharmacodynamics Sister-chromatid Exchanges

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• ISSN:
  0027-5107
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  99-102
• Volume:
  226
• Issue:
  2
• NIOSHTIC Number:
  nn:00205407
• Citation:
  Mutat Res 1989 Jun; 226(2):99-102
• CAS Registry Number:
  Mitomycin C (CAS RN 50-07-7) ; Tetrandrine (CAS RN 518-34-3)
• Federal Fiscal Year:
  1989
• Peer Reviewed:
  True
• Source Full Name:
  Mutation Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:00cd48698ccada96df7a068a77471194b6d4e5c3784c9af1850fc64c28ffa9911f2c1ef8b53f30194eb63c82a3f924f09de48de460b9c97e264b8e96415c67f7
• Download URL:
  https://stacks.cdc.gov/view/cdc/204611/cdc_204611_DS1.pdf
• File Type:
  [PDF - 246.35 KB ]