Effects of exposure to carbon disulphide on low density lipoprotein cholesterol concentration and diastolic blood pressure

Details

• Personal Author:
  Burkhart GA ; Egeland, Grace M. ; Fajen, John M. ; Hornung, Richard W. ; Lee, Shio T. ; Schnorr, Teresa M.
• Description:
  The relation of exposure to carbon-disulfide (75150) (CS2) to total serum cholesterol, low and high density lipoprotein cholesterol, triglyceride, and fasting glucose concentrations was examined. Systolic and diastolic blood pressure were also measured. Workers exposed to CS2 were recruited from employees who had a minimum of 1 year working in a viscose rayon manufacturing facility. Of the 273 men exposed at the site, 165 participated in the study. Of the 422 workers at the site who were not exposed, 245 participated. Exposure levels were determined for the exposed workers. Blood samples were collected for cholesterol, triglycerides, and glucose concentrations. Questionnaires were used to obtain information on work history, health and medications. Blood pressure was measured. The authors conclude that relatively moderate exposure to CS2 may increase low density lipoprotein, may raise the low density lipoprotein cholesterol (LDLc) concentration, and may raise the diastolic blood pressure. The high exposure group had an adjusted mean diastolic blood pressure that was 5mmHg greater than that of the low exposure group. Since the findings revealed a significant linear trend in LDLc concentration and diastolic blood pressure with increasing exposure to CS2, they support the NIOSH recommended exposure limit of 1 part per million. [Description provided by NIOSH]
• Subjects:
  Blood Cardiovascular Diseases Cardiovascular System Hazardous Substances Occupational Exposure Occupational Health Safety Sulfides Textile Industry
• Keywords:
  Blood-pressure Cardiovascular-system-disorders NIOSH-Author Occupational-exposure Serum-cholesterol Synthetic-fibers-industry Toxic-effects
• ISSN:
  0007-1072
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  287-293
• Volume:
  49
• Issue:
  4
• NIOSHTIC Number:
  nn:00206840
• Citation:
  Br J Ind Med 1992 Apr; 49(4):287-293
• CAS Registry Number:
  Carbon disulfide (CAS RN 75-15-0)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  True
• Source Full Name:
  British Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6b5f061cb3e8f22677ec7189d086153d34b1c0cab5ef9a9593db9143f7291f647d66d09fb6d8603f6b880f1441459c480a1932d30e452a1a133940ff186fae40
• Download URL:
  https://stacks.cdc.gov/view/cdc/204552/cdc_204552_DS1.pdf
• File Type:
  [PDF - 1.18 MB ]