Determination of albumin and hemoglobin adducts in workers exposed to styrene and styrene oxide

Details

• Personal Author:
  Jin Z ; Rappaport SM ; Yeowell-O'Connell K
• Description:
  A study of albumin and hemoglobin adduct formation in workers occupationally exposed to styrene (100425) and styrene-oxide (96093) was conducted. The study group consisted of 48 healthy workers employed at a factory manufacturing reinforced plastic boats during 1987 and 1988. Personal air exposures to styrene and styrene-oxide over a work shift were monitored for 1 year. Multiple blood samples were collected over a year. The hemoglobin and albumin were extracted and analyzed for cysteine and carboxylic acid adducts of styrene-oxide utilizing gas chromatography/mass spectrometry. Associations between the adduct concentrations and personal air styrene and styrene-oxide concentrations were analyzed by univariate or multivariate techniques. Personal air styrene and styrene-oxide exposures varied from 0.9 to 235mg/m3 and 13.4 to 525 micrograms per cubic meter (microg/m3), respectively. The mean exposure concentrations were 64.3mg/m3 and 159microg/m3. The mean styrene-oxide/hemoglobin adduct concentrations varied from 0.078 to 0.481 nanomole per gram protein (nmol/g). The mean styrene-oxide/albumin adduct concentrations varied from 0.290 to 1.80nmol/g. The styrene/hemoglobin concentrations showed no apparent association with styrene or styrene-oxide exposure. The concentrations of styrene/albumin adducts tended to increase linearly with increasing personal air styrene or styrene-oxide concentration. The associations were stronger for styrene-oxide than for styrene. The authors conclude that the stronger association between styrene-oxide/albumin adduct concentrations and styrene-oxide exposure than with styrene exposure suggests that styrene-oxide exposures, even though low, may be important for workers in the reinforced plastics industry. [Description provided by NIOSH]
• Subjects:
  Occupational Exposure Occupational Health Plastics Polycyclic Aromatic Hydrocarbons Safety Ships Solvents
• Keywords:
  Aromatic-hydrocarbons Biological-monitoring Boat-manufacturing-industry Chemical-binding Hemoproteins Industrial-hygiene Occupational-exposure Organic-solvents Reinforced-plastics
• ISSN:
  1055-9965
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; North Carolina ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  205-215
• Volume:
  5
• Issue:
  3
• NIOSHTIC Number:
  nn:00231200
• Citation:
  Cancer Epidemiol Biomark Prev 1996 Mar; 5(3):205-215
• CAS Registry Number:
  Styrene (CAS RN 100-42-5) ; Styrene oxide (CAS RN 96-09-3)
• Federal Fiscal Year:
  1996
• Performing Organization:
  University of California Berkeley, Berkeley, California
• Peer Reviewed:
  True
• Start Date:
  19850901
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• End Date:
  19931227
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:de943641277bc7f1a9c5e4cfc0d8e3730c833e30c2aca6b70e1540f4d88091d431970b2b35aff062c82cf744cbba7f77274c8b3e215b9964ed52c9298fbcc1bd
• Download URL:
  https://stacks.cdc.gov/view/cdc/204461/cdc_204461_DS1.pdf
• File Type:
  [PDF - 1.57 MB ]