Antimutagenicity studies of chlorophyllin using the Salmonella arabinose-resistant assay system

Details

• Personal Author:
  Nath J ; Ong M ; Warner JR
• Description:
  A study was designed to determine the inhibitory effect of chlorophyllin (11006921) against the mutagenic activity of different chemical compounds such as aflatoxin-B1 (1162658) (AFB1), 2- aminoanthracene (613138) (2AA), benzo(a)pyrene (50328) (BaP), N- methyl-N'-nitro-N-nitrosoguanidine (70257) (MNNG) and complex mixtures of airborne and diesel emission particles, coal dust, tobacco snuff, black pepper and red wine using the Salmonella- arabinose resistant forward mutation assay system. Various concentrations of each chemical and complex mixture extract were assayed for mutagenic activity with and/or without S9 in a preincubation test. One concentration of each chemical and complex mixture extract was then tested with various concentrations of chlorophyllin. Results indicated that chlorophyllin, at concentrations of 2.5 milligrams/plate or less, completely or almost completely inhibited the mutagenicity of 2AA, AFB2, BaP, MNNG, and solvent extracts of coal dust, diesel emission, and red wine. With concentrations from 1.25 to 5 milligrams/plate, chlorophyllin inhibited over 50% of the mutagenicity of airborne particles, tobacco snuff, and black pepper extracts. The authors conclude that these results further substantiate the antimutagenic efficacy of chlorophyllin against chemicals and complex mixtures. [Description provided by NIOSH]
• Subjects:
  Cells, Cultured Cytotoxins Dust Mutagens Occupational Health Pyrenes Safety Vehicle Emissions
• Keywords:
  Analytical-methods Antimutagen Aribinose-resistant Author Keywords: Chlorophyllin Cell-cultures Complex Mixture Cytotoxic-effects Diesel-exhausts Forward-mutation Assay Mineral-dusts NIOSH-Author Salmonella Typhimurium Tobacco-dusts

  More +
• ISSN:
  0027-5107
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  25-30
• Volume:
  262
• Issue:
  1
• NIOSHTIC Number:
  nn:00204896
• Citation:
  Mutat Res 1991 Jan; 262(1):25-30
• CAS Registry Number:
  2-Aminoanthracene (CAS RN 613-13-8) ; Aflatoxin B1 (CAS RN 1162-65-8) ; Benzo[a]pyrene (CAS RN 50-32-8) ; Magnesate(3-), [(7S,8S)-3-carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphine-7-propanoato(5-)-κN21,κN22,κN23,κN24]-, hydrogen (1:3), (SP-4-2)- (CAS RN 11006-92-1) ; N-Methyl-N′-nitro-N-nitrosoguanidine (CAS RN 70-25-7)
• Federal Fiscal Year:
  1991
• Peer Reviewed:
  True
• Source Full Name:
  Mutation Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f5fe687f25e7d64061e75b0f26242ecc00683bb735b4cfd42261bf9bc38bccbbf494aa2b3f1fa4b354fc2e9c9a6f27b87ba6c63179a0247c66959704f61fef81
• Download URL:
  https://stacks.cdc.gov/view/cdc/204175/cdc_204175_DS1.pdf
• File Type:
  [PDF - 365.98 KB ]