Influence of Particulates on Occupational Lung Disease

Details

• Personal Author:
  Miller M ; Radike M ; Talaska G ; Warshawsky D
• Description:
  The ability of alveolar macrophages (AM) to phagocytize uncoated and benzo(a)pyrene (50328) (BaP) coated particulates was investigated. AM from male Syrian-golden-hamsters and Sprague-Dawley-rats were used. Particulates included crystalline-silica (14808607); precipitated, gelled, and fumed amorphous-silica (7631869); ferric- oxide (1309371); and aluminum-oxide (1344281). All forms of amorphous silica had smaller particle sizes and were cytotoxic, suggesting that more of the dose for the amorphous silicas entered the AM. Toxicity also appeared related to the surface properties, with those particles having more silanol groups being more cytotoxic. These same properties were important in the metabolic activation of BaP by AM. At a similar dose of BaP and particle, all of the BaP coated particles produced more BaP dihydrodiols than BaP alone. AM exposed to particles coated with BaP responded differently than either BaP or particles alone at noncytotoxic doses. For metabolism, DNA binding and cytotoxicity parameters, the surface area of the particle appeared to play a major role. [Description provided by NIOSH]
• Subjects:
  Cells, Cultured Dust Hydrocarbons Lung Lung Diseases Occupational Health Polycyclic Aromatic Hydrocarbons Pyrenes Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Alveolar-cells Cell-cultures Lung-disease Mineral-dusts NIOSH-Grant Polycyclic-aromatic-hydrocarbons Pulmonary-system-disorders Respiratory-system-disorders
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-34
• NIOSHTIC Number:
  nn:00228266
• NTIS Accession Number:
  PB95-267878
• Citation:
  Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 1994 Jun; :1-34
• Contact Point Address:
  Environmental Health University of Cincinnati 3223 Eden Ave - M L #56 Cincinnati, OH 45267-0056
• CAS Registry Number:
  Alumina (CAS RN 1344-28-1) ; Benzo[a]pyrene (CAS RN 50-32-8) ; Iron oxide (Fe2O3) (CAS RN 1309-37-1) ; Quartz (SiO2) (CAS RN 14808-60-7) ; Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  False
• Start Date:
  19860701
• Source Full Name:
  Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio
• End Date:
  19970331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:697ca0903ae736a3f3beb70a4586525469596f2c23b06ab693d7a90d1e84ef0acd0d1e0c4459edee6bf1e896686ccfc66b5c979784e82e1a97305890cd943ff1
• Download URL:
  https://stacks.cdc.gov/view/cdc/217844/cdc_217844_DS1.pdf
• File Type:
  [PDF - 1.82 MB ]