Anorexia nervosa. Immaturity of the 24-hour luteinizing hormone secretory pattern

Details

• Personal Author:
  Boyar RM ; Finkelstein JW ; Hellman L ; Kapen S ; Katz J ; Weiner H ; Weitzman ED
• Description:
  Nine women, aged 17 to 23 years, with anorexia nervosa participated in this study of plasma luteinizing hormone (LH) concentrations measured at 20 minute intervals for 24 hours. Of these nine patients, eight demonstrated secretory patterns that resembled those of either normal prepubertal or pubertal, premenarchal girls. These LH secretory patterns were inappropriate for the patient's chronologic age, and suggested that a regression in the patients with secondary amenorrhea or an arrest in the patients with primary amenorrhea of the normal LH secretory program had occurred. Following treatment there was a maturation process from an early pubertal LH secretory pattern to one characteristic of adult women in one case which followed a return of body weight to normal and a clinical remission. This result indicated the importance of body weight as a determinant of the functional integrity of the hypothalamic pituitary gonadal axis. Data from other studies suggested that the gonadotropin abnormality probably originated in the central nervous system. A secondary finding was that changes in body weight may affect the spontaneous 24 hour LH secretory pattern and relate to the sequential changes that occur in the LH secretory pattern during normal sexual maturation. [Description provided by NIOSH]
• Subjects:
  Endocrine System Menstruation Disturbances Nervous System Diseases Occupational Health Safety Urogenital Diseases
• Keywords:
  Endocrine-system Gonadotropic-hormones Hormone-activity Hormones Menstrual-disorders Nervous-system-disorders Reproductive-system-disorders
• ISSN:
  0028-4793
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  291
• Issue:
  17
• NIOSHTIC Number:
  nn:00190458
• Citation:
  N Engl J Med 1974 Oct; 291(17):861-865
• Contact Point Address:
  Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
• Federal Fiscal Year:
  1975
• NORA Priority Area:
  Grants Other
• Performing Organization:
  Montefiore Hospital and Medical Center, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  New England Journal of Medicine
• End Date:
  19761231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f3d33412c7a84424b70ab2e011088783046db69486933a2b44b5883558b2c333af71ff5a18da45ec82a949b9893a2261d9f2b653bd6ffeb3b06f196d4df6bda6
• Download URL:
  https://stacks.cdc.gov/view/cdc/204171/cdc_204171_DS1.pdf
• File Type:
  [PDF - 684.92 KB ]