A case-control study of cancer mortality at a transformer-assembly facility

Details

• Personal Author:
  Greenland S ; Hallock MF ; Salvan A ; Smith, Thomas J. ; Wegman, David H.
• Description:
  A case/control study was carried out of cancer associated mortality at a transformer assembly factory in Massachusetts. Seven types of exposure with mutagenic or carcinogenic potential were rated together with the operations in which they were used. The chemicals were pyranol (1336363), benzene (71432), trichloroethylene (79016) (TCE), mixed solvents, machining fluids, asbestos (1332214), and synthetic resins. The cohort consisted of 1,821 white male subjects with 51,063 person years of employment. Site specific cancer deaths were regarded as cases, and comparisons were selected from deaths considered unassociated with any of the exposures. Odds ratios (ORs) were calculated. Results showed that 28 exposure/cancer associations could be identified as important in the binary exposure regressions or in the contingency table screening. Pyranol lymphomas and solvent oral/laryngeal/pharyngeal cancers showed a greatly reduced association, whereas a consistent positive association was evident between benzene and brain tumors, other solvents and lymphomas, and resins with lung cancer. Regressions with multiple exposures were also computed. A modification of the induction latency analysis method was used, and the only notable finding was an association between machining fluids and kidney cancer. Associations of resins with rectal and lung cancer, machining fluids with kidney cancer, and TCE with leukemias seemed to be largely or entirely concentrated to post 1950 exposures. Cross tabulation showed a similar association between level 2 solvents and reticulosarcoma. The authors conclude that the link between machining fluids and kidney cancer is new, and that this as well as a possible association between lung cancer and resin systems deserve further investigation. [Description provided by NIOSH]
• Subjects:
  Carcinogens Lung Lung Diseases Manufacturing And Industrial Facilities Mortality Neoplasms Occupational Exposure Occupational Health Polychlorinated Biphenyls Respiratory System Respiratory Tract Diseases Risk Assessment Safety

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• Keywords:
  Cancer-rates Electrical-equipment Industrial-factory-workers Lung-cancer Mortality-surveys NIOSH-Author Occupational-exposure Polychlorinated-biphenyls Risk-analysis Synthetic-resins
• ISSN:
  0340-0131
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; Ohio ; OSHA Region 1 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  49-54
• Volume:
  66
• Issue:
  1
• NIOSHTIC Number:
  nn:00220970
• Citation:
  Int Arch Occup Environ Health 1994 May; 66(1):49-54
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; Asbestos (CAS RN 1332-21-4) ; Benzene (CAS RN 71-43-2) ; Trichloroethylene (CAS RN 79-01-6)
• Federal Fiscal Year:
  1994
• Peer Reviewed:
  True
• Source Full Name:
  International Archives of Occupational and Environmental Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1c7890fef4bbf562076823f03b9b432bfb4fcba296ecff2d3a0e37631da5dcbfa3f47d8e268f7968f7a1e784f019f90b357c838fa146cd133edc6f8125161ffe
• Download URL:
  https://stacks.cdc.gov/view/cdc/203981/cdc_203981_DS1.pdf
• File Type:
  [PDF - 633.50 KB ]