Cancer incidence among capacitor manufacturing workers exposed to polychlorinated biphenyls

Details

• Personal Author:
  Hein, Misty J. ; Hopf NB ; Ruder, Avima M. ; Waters MA
• Description:
  Background: We evaluated cancer incidence in a cohort of polychlorinated biphenyl (PCB) exposed workers. Methods: Incident cancers, identified using state registries, were compared to those in a national population using standardized incidence ratios. Trends in prostate cancer incidence with cumulative PCB exposure were evaluated using standardized rate ratios and Cox regression models. For selected sites, cumulative PCB exposure was compared between aggressive (fatal/distant stage) and localized/regional cancers. Results: We identified 3,371 invasive first primary cancer diagnoses among 21,317 eligible workers through 2007. Overall relative incidence was reduced. Elevations were only observed for respiratory cancers and among women, urinary organ cancers. Among men, prostate cancer incidence was reduced and not associated with cumulative PCB exposure although median exposures were significantly higher for aggressive compared to localized/regional prostate cancers. Conclusion: Previously observed associations between cumulative PCB exposure and prostate cancer mortality were not confirmed in this analysis; prostate cancer stage at diagnosis may explain the discrepancy. Description provided by NIOSH
• Subjects:
  • Cohort Studies
  • Manufacturing and Industrial Facilities
  • Neoplasms
  • Occupational Exposure
  • Occupational Health
  • Polychlorinated Biphenyls
  • Safety
• Keywords:
  • Cancer
  • Polychlorinated biphenyls
  • PCBs
  • Cancer registries
  • Prostate cancer
  • Manufacturing
  • Cohort studies
  • Statistical analysis
  • Employee exposure
  • Regression analysis
  More +
• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  198-207
• Volume:
  60
• Issue:
  2
• NIOSHTIC Number:
  nn:20049085
• Citation:
  Am J Ind Med 2017 Feb; 60(2):198-207
• Contact Point Address:
  Avima M. Ruder, PhD, NIOSH, DSHEFS, IWSB, 1090 Tusculum Avenue, Mailstop R-15, Cincinnati, OH 45226
• Email:
  amr2@cdc.gov
• CAS Registry Number:
  • 1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3)
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Download URL:
  https://stacks.cdc.gov/view/cdc/203658/cdc_203658_DS1.pdf
• File Type:
  [PDF - 111.24 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9e11b8d5afe53991f1d607c5997330816163a6b671a001f4445e7d8164ccc7ff636c293868f041338a02e015b142ee50aeaf357cc319b1020d9a51555e7a9ab1