Inhalation of gas metal arc-stainless steel welding fume promotes lung tumorigenesis in A/J mice

Details

• Personal Author:
  Andrews R ; Antonini J ; Battelli L ; Cumpston A ; Cumpston J ; Erdely A ; Falcone L ; Kashon M ; McKinney W ; Meighan T ; Salmen R ; Stone S ; Zeidler-Erdely P
  More +
• Description:
  Epidemiologic studies suggest an increased risk of lung cancer with exposure to welding fumes, but controlled animal studies are needed to support this association. Oropharyngeal aspiration of gas metal arc-stainless steel (GMA-SS) welding fume has been shown by our laboratory to promote lung tumor formation in vivo using a two-stage initiation-promotion model. Our objective in this study was to determine if GMA-SS fume also acts as a lung tumor promoter when delivered via inhalation to lung tumor susceptible mice. Male A/J mice received intraperitoneal (IP) injections of corn oil or the chemical initiator 3-methylcholanthrene (MCA;10 microg/g) and one week later were exposed by whole body inhalation to air or GMA-SS welding aerosols for 4 h/d x 4 d/w x 9 w at a target concentration of 40 mg/m3. Lung nodules were enumerated at 30 weeks post-initiation. GMA-SS fume significantly promoted lung tumor multiplicity in A/J mice initiated with MCA (16.11 +/- 1.18) compared to MCA/air-exposed mice (7.93 +/- 0.82). Histopathological analysis found that the increased number of lung nodules in the MCA/ GMA-SS group were hyperplasias and adenomas, which was consistent with developing lung tumorigenesis. Lung metal deposition analysis revealed that a markedly lower deposited dose (approximately 5 fold) elicited a similar fold-change lung tumorigenic response when compared to our previous aspiration study. In conclusion, this study demonstrates that inhalation of GMA-SS welding fume promotes lung tumor formation in vivo and provides further support for the epidemiologic studies that show welders are at an increased risk for lung cancer. Description provided by NIOSH
• Subjects:
  • Aerosols
  • Carcinogens
  • Lung
  • Lung Diseases
  • Neoplasms
  • Occupational Health
  • Respiratory System
  • Respiratory Tract Diseases
  • Safety
  • Toxicology
  More +
• Keywords:
  • Welding fumes
  • Inhalation
  • Aerosols
  • Tumorigenesis
  • Lung cancer
  • Toxicology
  • Stainless steel
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  156
• Issue:
  1
• NIOSHTIC Number:
  nn:20049460
• Citation:
  Toxicologist 2017 Mar; 156(1):327
• CAS Registry Number:
  • Stainless Steel (CAS RN 12597-68-1)
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 56th Annual Meeting and ToxExpo, March 12-16, 2017, Baltimore, Maryland
• Download URL:
  https://stacks.cdc.gov/view/cdc/203904/cdc_203904_DS1.pdf
• File Type:
  [PDF - 951.12 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4b968e36bab086f189080d698c396a750f42cc7eed4222b876dc80f09f023776520a13559d0e5ef6ffe48e18905eedd77dbd0fb5606e9747efde1195a60dd024