Absence of Lung Tumor Promotion with Reduced Tumor Size in Mice After Inhalation of Copper Welding Fumes

Details

• Personal Author:
  Antonini JM ; Battelli LA ; Betler E ; Erdely A ; Falcone LM ; Friend S ; Grose L ; Hobbie KR ; Kashon M ; Kodali V ; Leonard, Stephen S. ; McKinney W ; Meighan TG ; Mercer R ; Salmen R ; Service S ; Stefaniak, Aleksandr B. ; Stone S ; Trainor-DeArmitt T ; Zeidler-Erdely PC
• Description:
  Welding fumes are a Group 1 (carcinogenic to humans) carcinogen as classified by the International Agency for Research on Cancer. The process of welding creates inhalable fumes rich in iron (Fe) that may also contain known carcinogenic metals such as chromium (Cr) and nickel (Ni). Epidemiological evidence has shown that both mild steel (Fe-rich) and stainless steel (Fe-rich + Cr + Ni) welding fume exposure increases lung cancer risk, and experimental animal data support these findings. Copper-nickel (CuNi) welding processes have not been investigated in the context of lung cancer. Cu is intriguing, however, given the role of Cu in carcinogenesis and cancer therapeutics. This study examines the potential for a CuNi fume to induce mechanistic key characteristics of carcinogenesis in vitro and to promote lung tumorigenesis, using a two-stage mouse bioassay, in vivo. Male A/J mice, initiated with 3-methylcholanthrene (MCA; 10 µg/g), were exposed to CuNi fumes or air by whole-body inhalation for 9 weeks (low deposition-LD and high deposition-HD) and then sacrificed at 30 weeks. In BEAS-2B cells, the CuNi fume-induced micronuclei and caused DNA damage as measured by y-H2AX. The fume exhibited high reactivity and a dose-response in cytotoxicity and oxidative stress. In vivo, MCA/CuNi HD and LD significantly decreased lung tumor size and adenomas. MCA/CuNi HD exposure significantly decreased gross-evaluated tumor number. In summary, the CuNi fume in vitro exhibited characteristics of a carcinogen, but in vivo, the exposure resulted in smaller tumors, fewer adenomas, less hyperplasia severity, and with HD exposure, less overall lung lesions/tumors. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Cytotoxins Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety Welding

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• Keywords:
  Animal Studies Author Keywords: Metals Carcinogenesis Copper Fumes Cytotoxicity Inhalation Lung Cancer Strain A Mouse Tumorigenesis Two-stage Bioassay Welding Fumes

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• ISSN:
  0143-3334
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  45
• Issue:
  9
• NIOSHTIC Number:
  nn:20069939
• Citation:
  Carcinogenesis 2024 Sep; 45(9):630-641
• Contact Point Address:
  Patti C Zeidler-Erdely, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26508, United States
• Email:
  paz9@cdc.gov
• Federal Fiscal Year:
  2024
• Peer Reviewed:
  True
• Source Full Name:
  Carcinogenesis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e54620914eb66a07e03d070a373059dfcaff07f486bd4dab29d611b684d9670fac0aa24682d44e06c2f1b5c3efcd469197bbf2ec3e473b6eae5e2632d464ac4
• Download URL:
  https://stacks.cdc.gov/view/cdc/208258/cdc_208258_DS1.pdf
• File Type:
  [PDF - 21.98 MB ]