Urinary bisphenol A (BPA) concentrations among workers in industries that manufacture and use BPA in the USA

Details

• Personal Author:
  Calafat, Antonia M. ; Christianson AL ; Clark JC ; Deddens JA ; Hines CJ ; Jackson MV ; Meadows JW ; Ye X
• Description:
  Background: Bisphenol A (BPA) toxicity and exposure risk to humans has been the subject of considerable scientific debate; however, published occupational exposure data for BPA are limited. Methods: In 2013-2014, 77 workers at six US companies making BPA, BPA-based resins, or BPA-filled wax provided seven urine samples over two consecutive work days (151 worker-days, 525 samples). Participant information included industry, job, tasks, personal protective equipment used, hygiene behaviors, and canned food/beverage consumption. Total (free plus conjugated) BPA, quantified in urine by mass spectrometry, was detected in all samples. Results: The geometric mean (GM) creatinine-adjusted total BPA (total BPACR) concentration was 88.0 ug g-1 (range 0.78-18 900 ug g-1), approximately 70 times higher than in US adults in 2013-2014 (1.27 ug g-1). GM total BPACR increased during Day 1 (26.6-127 ug g-1), decreased by pre-shift Day 2 (84.4 ug g-1) then increased during Day 2 to 178 ug g-1. By industry, baseline and post-baseline total BPACR was highest in BPA-filled wax manufacturing/reclaim (GM = 111 ug g-1) and lowest in phenolic resin manufacturing (GM = 6.56 ug g-1). By job, total BPACR was highest at baseline in maintenance workers (GM = 157 ug g-1) and post-baseline in those working with molten BPA-filled wax (GM = 441 ug g-1). Workers in the job of flaking a BPA-based resin had the lowest concentrations at baseline (GM = 4.81 ug g-1) and post-baseline (GM = 23.2 ug g-1). In multiple regression models, at baseline, industry significantly predicted increased total BPACR (P = 0.0248); post-baseline, handling BPA containers (P = 0.0035), taking >3 process/bulk samples with BPA (P = 0.0002) and wearing a Tyvek coverall (P = 0.0042) significantly predicted increased total BPACR (after adjusting for total BPACR at baseline, time point, and body mass index). Conclusion: Several work-related factors, including industry, job, and certain tasks performed, were associated with increased urinary total BPACR concentrations in this group of manufacturing workers. The potential for BPA-related health effects among these workers is unknown. [Description provided by NIOSH]
• Subjects:
  Chemistry Manufacturing And Industrial Facilities Occupational Health Safety Urine Urogenital System
• Keywords:
  Author Keywords: Biological Monitoring Biological Monitoring Bisphenol A Chemical Manufacturing Industry Chemical Properties Determinants Of Exposure Exposure Assessment Occupational Groups Reproductive Health Urinalysis Urine Analysis

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• ISSN:
  2398-7308
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; South Carolina
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; OD - Office of the Director ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  164-182
• Volume:
  61
• Issue:
  2
• NIOSHTIC Number:
  nn:20049449
• Citation:
  Ann Work Expo Health 2017 Mar; 61(2):164-182
• Contact Point Address:
  Cynthia J. Hines, National Institute for Occupational Safety and Health, 1090 Tusculum Ave, R-14, Cincinnati, OH 45226
• Email:
  chines@cdc.gov
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Annals of Work Exposures and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:22c56d20dac658ce90bf0a38ad4c2069212ed1546660b64c65c59c431888c26739b83caf269de900fc1485a9d7d38aadb21265e925bc9ffcd85065ac73a9fdbe
• Download URL:
  https://stacks.cdc.gov/view/cdc/203893/cdc_203893_DS1.pdf
• File Type:
  [PDF - 564.28 KB ]