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Urinary Bisphenol A (BPA) Concentrations among Workers in Industries that Manufacture and Use BPA in the USA
  • Published Date:
    Mar 01 2017
  • Source:
    Ann Work Expo Health. 61(2):164-182.


Public Access Version Available on: March 01, 2018 information icon
Please check back on the date listed above.
Details:
  • Pubmed ID:
    28395354
  • Pubmed Central ID:
    PMC5577557
  • Description:
    Background

    Bisphenol A (BPA) toxicity and exposure risk to humans has been the subject of considerable scientific debate; however, published occupational exposure data for BPA are limited.

    Methods

    In 2013–2014, 77 workers at six US companies making BPA, BPA-based resins, or BPA-filled wax provided seven urine samples over two consecutive work days (151 worker-days, 525 samples). Participant information included industry, job, tasks, personal protective equipment used, hygiene behaviors, and canned food/beverage consumption. Total (free plus conjugated) BPA, quantified in urine by mass spectrometry, was detected in all samples.

    Results

    The geometric mean (GM) creatinine-adjusted total BPA (total BPACR) concentration was 88.0 μg g−1 (range 0.78–18 900 μg g−1), ~70 times higher than in US adults in 2013–2014 (1.27 μg g−1). GM total BPACR increased during Day 1 (26.6–127 μg g−1), decreased by pre-shift Day 2 (84.4 μg g−1) then increased during Day 2 to 178 μg g−1. By industry, baseline and post-baseline total BPACR was highest in BPA-filled wax manufacturing/reclaim (GM = 111 μg g−1) and lowest in phenolic resin manufacturing (GM = 6.56 μg g−1). By job, total BPACR was highest at baseline in maintenance workers (GM = 157 μg g−1) and post-baseline in those working with molten BPA-filled wax (GM = 441 μg g−1). Workers in the job of flaking a BPA-based resin had the lowest concentrations at baseline (GM = 4.81 μg g−1) and post-baseline (GM = 23.2 μg g−1). In multiple regression models, at baseline, industry significantly predicted increased total BPACR (P = 0.0248); post-baseline, handling BPA containers (P = 0.0035), taking ≥3 process/bulk samples with BPA (P = 0.0002) and wearing a Tyvek® coverall (P = 0.0042) significantly predicted increased total BPACR (after adjusting for total BPACR at baseline, time point, and body mass index).

    Conclusion

    Several work-related factors, including industry, job, and certain tasks performed, were associated with increased urinary total BPACR concentrations in this group of manufacturing workers. The potential for BPA-related health effects among these workers is unknown.

  • Document Type:
  • Collection(s):
  • Funding:
    CC999999/Intramural CDC HHS/United States
  • Supporting Files:
    No Additional Files
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