Chip-scale gas chromatography

Details

• Personal Author:
  Akbar M
• Description:
  Instrument miniaturization is led by the desire to perform rapid diagnosis in remote areas with high throughput and low cost. In addition, miniaturized instruments hold the promise of consuming small sample volumes and are thus less prone to cross-contamination. Gas chromatography (GC) is the leading analytical instrument for the analysis of volatile organic compounds (VOCs). Due to its wide-ranging applications, it has received great attention both from industrial sectors and scientific communities. Recently, numerous research efforts have benefited from the advancements in micro-electromechanical system (MEMS) and nanotechnology based solutions to miniaturize the key components of GC instrument (pre-concentrator/injector, separation column, valves, pumps, and the detector). The purpose of this dissertation is to address the critical need of developing a micro GC system for various field- applications. The uniqueness of this work is to emphasize on the importance of integrating the basic components of µGC (including sampling/injection, separation and detection) on a single platform. This integration leads to overall improved performance as well as reducing the manufacturing cost of this technology. In this regard, the implementation of micro helium discharge photoionization detector (µDPID) in silicon-glass architecture served as a major accomplishment enabling its monolithic integration with the micro separation column (µSC). For the first time, the operation of a monolithic integrated module under temperature and flow programming conditions has been demonstrated to achieve rapid chromatographic analysis of a complex sample. Furthermore, an innovative sample injection mechanism has been incorporated in the integrated module to present the idea of a chip-scale µGC system. The possibility of using µGC technology in practical applications such as breath analysis and water monitoring is also demonstrated. Moreover, a nanotechnology based scheme for enhancing the adsorption capacity of the microfabricated pre-concentrator is also described. [Description provided by NIOSH]
• Subjects:
  Chemistry Chromatography Occupational Health Safety Volatile Organic Compounds
• Keywords:
  Author Keywords: MEMS Biomedical-engineering Breath Analysis Chemical-analysis Chemical-composition Chemical-properties Chemical Detectors Chromatographic Analysis Electromechanical Systems Gas-chromatography Gas Chromatography Lab-on-a-Chip Microfluidics Monitoring-systems Monitoring Systems Nanotechnology Organic-compounds Separation Column VOCs Volatile Organic Compounds Volatiles

  More +
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Dissertation
• Place as Subject:
  OSHA Region 3 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-117
• NIOSHTIC Number:
  nn:20048902
• Citation:
  Blacksburg, VA: Virginia Polytechnic Institute and State University, 2015 Aug; :1-117
• Federal Fiscal Year:
  2015
• Performing Organization:
  Virginia Polytechnic Institute and State University
• Peer Reviewed:
  False
• Start Date:
  20120701
• Source Full Name:
  Chip-scale gas chromatography
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:37753aeef2415fb4957447132cdbe074e5635d1318d0b3723037e8f92cc5533b3492c787b9526948a7be6dc3f2c3065788a7c31e7e22ce61e8c10ffabff5fc65
• Download URL:
  https://stacks.cdc.gov/view/cdc/203521/cdc_203521_DS1.pdf
• File Type:
  [PDF - 4.81 MB ]