High-Sensitivity Micro-Gas Chromatograph-Photoionization Detector for Trace Vapor Detection

Details

• Personal Author:
  Fan X ; Ghosh A ; Huang X ; Li MW-H ; Sharma R ; Venkatasubramanian A
• Description:
  Rapid in situ detection and analysis of trace vapor concentrations at a sub-parts per billion to parts per trillion level remains a challenge for many applications such as indoor air-quality analysis and detection of explosives and narcotics. Micro-gas chromatography (µGC) together with a micro-photoionization detector (µPID) is a prominent method for portable analysis of complex vapor mixtures, but current µPID technology demonstrates poor detection performance compared to benchtop flame ionization detectors (FIDs). This work demonstrates the development of a significantly improved µPID with a sub-picogram detection limit (as low as approx. 0.2 pg) comparable to or exceeding that of a benchtop FID, with a large linear dynamic range (>4 orders of magnitude) and robustness (high stability over 200 h of plasma activation). Based on this µPID, a complete µGC-PID system was built and tested on standard sample chromatograms in a laboratory setting to show the system's analytical capabilities and the detection limit down to sub-parts per trillion concentrations (as low as 0.14 ppt). Practical in-field chromatograms on breath and car exhaust were also generated to demonstrate applicability for in situ experimentation. This work shows that µGC-PID systems can be competitive with traditional GC-FID methods and thus opens a door to rapid trace vapor analysis in the field. [Description provided by NIOSH]
• Subjects:
  Chromatography Occupational Health Safety Solvents Volatile Organic Compounds
• Keywords:
  Analytical Instruments Author Keywords: Photoionization Detector Chromatographic Analysis Gas Chromatography High Sensitivity Limit Of Detection LOD Low Detection Limit Portable Gas Chromatography Trace Analysis Trace Vapor Analysis Vapors VOCs Volatile Organic Compounds

  More +
• ISSN:
  2379-3694
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  6
• Issue:
  6
• NIOSHTIC Number:
  nn:20063069
• Citation:
  ACS Sens 2021 Jun; 6(6):2348-2355
• Contact Point Address:
  Xudong Fan, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United States
• Email:
  xsfan@umich.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of Michigan at Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20180901
• Source Full Name:
  ACS Sensors
• End Date:
  20220831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1fda8c3a15378c39c676b3e4c63e739ff76533f166eecfacfa2d83dcd614436e17251e30d60224ce5b839d98e8bf7c556adae1b4d313d29fd2b31dd729f6f414
• Download URL:
  https://stacks.cdc.gov/view/cdc/226197/cdc_226197_DS1.pdf
• File Type:
  [PDF - 2.03 MB ]