CoO and La2O3 nanoparticle-induced pulmonary response in mice after whole-body inhalation exposure

Details

• Personal Author:
  Andrew, Michael E. ; Battelli L ; Castranova, Vincent ; Chen BT ; McKinney W ; Mercer R ; Mihalchik A ; Porter, Dale ; Qian Y ; Shaffer J ; Sisler JD ; Wolfarth M
• Description:
  Metal oxide nanoparticles have the unique property of semi-conduction and can serve as conduits for electron transfer between aqueous reactants. Studies have shown that these semi-conducting properties may be responsible for generating adverse health effects. Two metal oxide nanoparticles with different semi-conductor properties, cobalt monoxoide (CoO) and lanthanum oxide (La2O3) may pose different toxicological potentials in vivo and in vitro. Our previous in vitro study showed that CoO nanoparticles induce a more potent toxicological response in human small airway epithelial cells than La 2O3 nanoparticles. The current study determined CoO and La2O3 metal oxide nanoparticles-induced pulmonary response in mice after whole-body inhalation exposure. Mice were exposed to 10 or 30 mg/m 3, for 6 h per day over 4 days and were examined at 1, 7 and 56 days post exposure. Both CoO and La 2O3 nanoparticles were present in the lung at 1, 7 and 56 days post exposure; however, CoO caused greater lactate dehydrogenase, macrophages, lymphocytes, neutrophils and eosinophils in the bronchoalveolar fluid compared to La2O3 nanoparticles at both doses and all post exposure time points. Histopathological results show that there was acute pulmonary inflammation at 1 day post-exposure for both nanoparticles; however, no chronic fibrotic response was observed. Mice exposed to CoO had higher levels of proinflammatory cytokine expression compared to mice exposed to La 2O3 nanoparticles. Taken together, the results demonstrate that CoO nanoparticles induce more overall acute pulmonary toxicity when compared to La2O3 nanoparticles. Moreover, this study starts to fills the gap between in vivo and in vitro nanoparticle-induced toxicity studies and risk assessment. [Description provided by NIOSH]
• Subjects:
  Blood Chemistry Laboratories Lung Lung Diseases Macrophages Occupational Health Respiratory System Respiratory Tract Diseases Safety Semiconductors Toxicology

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• Keywords:
  Airway Resistance Alveolar Cells Chemical Properties Cobalt Oxides Dose Response Exposure Assessment Inhalation Studies In Vitro Study Laboratory Animals Laboratory Testing Lanthanum Oxide Lymphocytes Metal Oxides Nanotechnology Neutrophils Physical Properties Pulmonary System Disorders

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• Publisher:
  Keystone Symposia
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Colorado ; OSHA Region 3 ; OSHA Region 8 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20048487
• Citation:
  Fibrosis: from basic mechanisms to targeted therapies joint with the meeting on stromal cells in immunity, February 7-11, 2016, Keystone, Colorado. Silverthorne, CO: Keystone Symposia, 2016 Feb; :104
• CAS Registry Number:
  Cobalt oxide (CoO) (CAS RN 1307-96-6) ; Lanthanum sesquioxide (CAS RN 1312-81-8)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Fibrosis: from basic mechanisms to targeted therapies joint with the meeting on stromal cells in immunity, February 7-11, 2016, Keystone, Colorado
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3cd00feceefb20bed0108442c9de10162d8a27e6ba1542e6b524b673c04953f6f38e60102f06c3cb2ae97cd623b0e011a8e91aec539929ab3cfa6f7fc9179405
• Download URL:
  https://stacks.cdc.gov/view/cdc/203234/cdc_203234_DS1.pdf
• File Type:
  [PDF - 96.80 KB ]