CoO and La2O3 nanoparticle-induced pulmonary response in mice after whole-body inhalation exposure

Details

• Personal Author:
  Andrew, Michael E. ; Battelli L ; Castranova, Vincent ; Chen BT ; McKinney W ; Mercer R ; Mihalchik A ; Porter, Dale ; Qian Y ; Shaffer J ; Sisler JD ; Wolfarth M
• Description:
  Metal oxide nanoparticles have the unique property of semi-conduction and can serve as conduits for electron transfer between aqueous reactants. These semi-conducting properties are implicated in adverse health effects. Two metal oxide nanoparticles with different semi-conductor properties, cobalt monoxide (CoO) and lanthanum oxide (La2O3) may pose different toxicological potentials in vivo and in vitro. Our previous in vitro study showed that CoO nanoparticles induce a more potent toxicological response in human small airway epithelial cells than La2O3 nanoparticles. The current study determined CoO and La2O3 nanoparticles-induced pulmonary response in mice after wholebody inhalation exposure. Mice were exposed to 10 or 30 mg/m3, for 6 h per day over 4 days and were examined at 1, 7 and 56 days post-exposure. Both CoO and La2O3 nanoparticles were present in the lung at 1, 7 and 56 days post-exposure. CoO caused greater lactate dehydrogenase in the bronchoalveolar fluid compared to La2O3 at 1 day post exposure at both doses. La2O3 had elevated numbers of macrophages, lymphocytes, neutrophils and eosinophils in the bronchoalveolar fluid compared to CoO nanoparticles at both doses and all post-exposure time points. Histopathological results show that there was acute pulmonary inflammation at 1 day post-exposure for CoO and an inflammation at 7 day post exposure for La2O3 Fibrosis was not observed at 56 day post-exposure at 10 and 30 mg/m3. Mice exposed to CoO and La2O3 have different expression patterns of pro-inflammatory cytokines at all post exposure time points and doses. Taken together, the results demonstrate that CoO nanoparticles induce more overall acute pulmonary toxicity where as La2O3 nanoparticles caused chronic inflammation. Moreover, this study may fill the gap between in vivo and in vitro nanoparticle-induced toxicity studies and risk assessment. [Description provided by NIOSH]
• Subjects:
  Blood Chemistry Laboratories Lung Lung Diseases Macrophages Occupational Health Respiratory System Respiratory Tract Diseases Safety Semiconductors Toxicology

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• Keywords:
  Airway Resistance Alveolar Cells Chemical Properties Cobalt Oxides Dose Response Exposure Assessment Inhalation Studies In Vitro Study Laboratory Animals Laboratory Testing Lanthanum Oxide Lymphocytes Metal Oxides Nanotechnology Neutrophils Physical Properties Pulmonary System Disorders

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Louisiana ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  150
• Issue:
  1
• NIOSHTIC Number:
  nn:20047698
• Citation:
  Toxicologist 2016 Mar; 150(1):362
• CAS Registry Number:
  Cobalt oxide (CoO) (CAS RN 1307-96-6) ; Lanthanum sesquioxide (CAS RN 1312-81-8)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 55th Annual Meeting and ToxExpo, March 13-17, 2016, New Orleans, Louisiana
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:418277246e7f00c428c6538af12b609a3895b6062ed82773bec14d15dacce97cd650901deee3f7baa6730ee842f36dbb118fc130eaf0eab3a9a4c31ea60a66ba
• Download URL:
  https://stacks.cdc.gov/view/cdc/202701/cdc_202701_DS1.pdf
• File Type:
  [PDF - 442.80 KB ]