Inflammatory response of mice following inhalation exposure to iron and copper nanoparticles

Details

• Personal Author:
  Adamcakova-Dodd A ; Grassian VH ; O'Shaughnessy PT ; Pettibone JM ; Thorne PS ; Weydert JA
• Description:
  We examined pulmonary inflammatory responses of mice following whole-body inhalation exposure to copper and iron nanoparticles in acute and sub-acute studies. Concentrations for sub-acute copper and iron exposures were 3.6 mg m-3. No significant pathology was found following acute exposure. Immediately following sub-acute exposure, both iron-and copper-exposed mice showed increased inflammation compared to sentinels. Copper nanoparticle-exposed mice had significantly higher lavage cytokines as well as perivasculitis and alveolitis. Three weeks post-exposure, all inflammatory markers decreased for iron nanoparticle-exposed mice, however, some remained elevated for copper-exposed mice. At biologically relevant pHs, in vitro studies showed that copper nanoparticles displayed a greater propensity for dissolution compared to iron. We conclude that the presence of dissolved ions, the concomitant formation of smaller nanoparticles and the absence of particles in stained lung sections immediately postexposure (inferring either translocation or more dispersed aerosol distribution) contributed to the increased inflammation observed in copper nanoparticle-exposed mice. [Description provided by NIOSH]
• Subjects:
  Aerosols Animals Copper Environmental Exposure Ferrous Compounds Laboratories Lung Lung Diseases Occupational Health Pathology Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Toxicology

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• Keywords:
  Agglomerates Author Keywords: Aerosol Cytokines Dissolution Exposure Levels Inhalation In Vitro Studies Iron Laboratory Animals Lung Disorders Murine Models Nanoparticles Nanotoxicology Risk Factors

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• ISSN:
  1743-5390
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  189-204
• Volume:
  2
• Issue:
  4
• NIOSHTIC Number:
  nn:20048399
• Citation:
  Nanotoxicology 2008 Dec; 2(4):189-204
• Contact Point Address:
  Vicki H. Grassian, Department of Chemistry, University of Iowa, Iowa City IA 52242
• Email:
  vicki-grassian@uiowa.edu
• CAS Registry Number:
  Copper (CAS RN 7440-50-8) ; Iron (CAS RN 7439-89-6)
• Federal Fiscal Year:
  2009
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20080401
• Source Full Name:
  Nanotoxicology
• End Date:
  20120331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8b738cd922f5dc839c4c695cdd33d585b89afc7e00242ae2dc34619ab0b25e2a001fbd17228b04a11ac75a25640944e8abb7c8a43a35247f19df0380df0325f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/203158/cdc_203158_DS1.pdf
• File Type:
  [PDF - 784.74 KB ]