Environmental exposure to manganese in air: associations with tremor and motor function

Details

• Personal Author:
  Beseler CL ; Bollweg G ; Bowler RM ; Colledge M ; Gocheva VV ; Julian JR ; Kim Y ; Kornblith ES ; Lobdell DT
• Description:
  Background: Manganese (Mn) inhalation has been associated with neuropsychological and neurological sequelae in exposed workers. Few environmental epidemiologic studies have examined the potentially neurotoxic effects of Mn exposure in ambient air on motor function and hand tremor in adult community residents. Mn exposed residents were recruited in two Ohio towns: Marietta, a town near a ferro-manganese smelter, and East Liverpool, a town adjacent to a facility processing, crushing, screening, and packaging Mn products. Methods: Chronic (>/=10 years) exposure to ambient air Mn in adult residents and effects on neuropsychological and neurological outcomes were investigated. Participants from Marietta (n = 100) and East Liverpool (n = 86) were combined for analyses. AERMOD dispersion modeling of fixed-site outdoor air monitoring data estimated Mn inhalation over a ten year period. Adult Mn-exposed residents' psychomotor ability was assessed using Finger Tapping, Hand Dynamometer, Grooved Pegboard, and the Computerized Adaptive Testing System (CATSYS) Tremor system. Bayesian structural equation modeling was used to assess associations between air- Mn and motor function and tremor. Results: Air-Mn exposure was significantly correlated in bivariate analyses with the tremor test (CATSYS) for intensity, center frequency and harmonic index. The Bayesian path analysis model showed associations of air-Mn with the CATSYS non-dominant center frequency and harmonic index; while the Bayesian structural equation model revealed associations between air-Mn and lower Finger Tapping scores. Household income was significantly associated with motor dysfunction but not with tremor. Conclusion: Tremor and motor function were associated with higher exposure to airborne Mn. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Community Health Services Environment Environmental Exposure Environmental Monitoring Manganese Manufacturing And Industrial Facilities Metals Metal Workers Nervous System Nervous System Diseases Occupational Health Pathology Respiratory System Safety

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• Keywords:
  Adult Residents Airborne Particles Air Monitoring Analytical Processes Author Keywords: Manganese Chemical Industry Workers Community Health Dispersion Environmental Exposure Exposure Assessment Humans Inhalation Models Neurological Disorders Neuromotor Function Neurophysiological Effects Neurotoxic Effects Neurotoxicity Psychomotor Psychomotor Function Smelters Tremor

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• ISSN:
  0048-9697
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; Illinois ; North Carolina ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  541
• NIOSHTIC Number:
  nn:20047938
• Citation:
  Sci Total Environ 2016 Jan; 541:646-654
• Contact Point Address:
  Rosemarie M. Bowler, 8371 Kent Drive, El Cerrito, CA 94530, United States
• Email:
  rbowl@sfsu.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2016
• Performing Organization:
  San Francisco State University
• Peer Reviewed:
  True
• Start Date:
  20080401
• Source Full Name:
  Science of the Total Environment
• End Date:
  20090331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:22cb7905039f4fd8df654a460831c41678053029566e175d426beef61acc09b3bb1988e34d56004fca56b26a7d345664f8b92495358f4c2c33defa5abd2c87ea
• Download URL:
  https://stacks.cdc.gov/view/cdc/202870/cdc_202870_DS1.pdf
• File Type:
  [PDF - 645.13 KB ]