Manganese and Neurobehavioral Impairment. A Preliminary Risk Assessment

Details

• Personal Author:
  Berg SL ; Park RM
• Description:
  Similar patterns of cognitive and motor deficits have been widely reported from manganese exposures in welding, metallurgical and chemical industry workers. A risk assessment was performed based on studies reported in the literature, extending some earlier work, and deriving new estimates of exposure response and excess risk. Many investigations of manganese neurological effects in humans have insufficient information to derive an exposure response; however, findings from a chemical manufacturer, two smelter and two welder populations permitted application of the benchmark dose procedure for continuous end-points. Small particles and aggregates of condensation fume (condensing vaporized metal, <0.1um in diameter) appear to have a higher potency per unit mass than larger particles from dusts (>1.0um). Consideration was given to long-term effects of continuous low exposures that instead of producing increasing toxicity attain a steady-state condition. Impairment was defined as excursions beyond the 5th percentile in a normal population and the concentrations of manganese predicted to result in 1% excess prevalence of impairment over different time periods were calculated. Over five years, exposures resulting in 1% excess prevalence of impairment (for purposes of discussion) were in the vicinity of 10ug/m3 for manganese fume and 25ug/m3 for larger particle dusts. These levels are below current recommendations for occupational limits on manganese exposure in the United States. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Behavior Dust Environmental Exposure Manganese Manufacturing And Industrial Facilities Metals Metal Workers Nervous System Nervous System Diseases Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Welding

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• Keywords:
  Author Keywords: Manganese Chemical Industry Workers Cognitive Function Dust Particles Dusts Exposure Levels Fumes Metallurgical Processes Metalworking Industry Neurobehavioral Neurological Disorders Particulate Dust Particulates Physiological Function Physiology Risk Assessment Risk Factors Smelter Steady State

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• ISSN:
  0161-813X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  159-165
• Volume:
  64
• NIOSHTIC Number:
  nn:20050299
• Citation:
  Neurotoxicology 2018 Jan; 64:159-165
• Contact Point Address:
  Robert M. Park Centers for Disease Control and Prevention National Institute for Occupational Safety and Health (NIOSH) 1090 Tusculum Ave, MS C-15 Cincinnati OH 45226-1998
• Email:
  rhp9@cdc.gov
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2018
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c8578de29800b636d64c2743c2894f7663d4f46a421acba84a65e317a780b93928f84582410341c231a6603331fd1c6b927bdc719dd91218c505362d150a2e5d
• Download URL:
  https://stacks.cdc.gov/view/cdc/210709/cdc_210709_DS1.pdf
• File Type:
  [PDF - 351.37 KB ]