Environmental exposure to manganese in air: associations with cognitive functions

Details

• Personal Author:
  Adams SW ; Beseler CL ; Bollweg G ; Bowler RM ; Colledge MA ; Gocheva VV ; Kim Y ; Kornblith ES ; Lobdell DT ; Wright CW
• Description:
  Manganese (Mn), an essential element, can be neurotoxic in high doses. This cross-sectional study explored the cognitive function of adults residing in two towns (Marietta and East Liverpool, Ohio, USA) identified as having high levels of environmental airborne Mn from industrial sources. Air-Mn site surface emissions method modeling for total suspended particulate (TSP) ranged from 0.03 to 1.61 microg/m(3) in Marietta and 0.01-6.32 microg/m(3) in East Liverpool. A comprehensive screening test battery of cognitive function, including the domains of abstract thinking, attention/concentration, executive function and memory was administered. The mean age of the participants was 56 years (+/- 10.8 years). Participants were mostly female (59.1) and primarily white (94.6%). Significant relationships (p<0.05) were found between Mn exposure and performance on working and visuospatial memory (e.g., Rey-O Immediate beta =-0.19, Rey-O Delayed beta =-0.16) and verbal skills (e.g., Similarities beta =-0.19). Using extensive cognitive testing and computer modeling of 10-plus years of measured air monitoring data, this study suggests that long-term environmental exposure to high levels of air-Mn, the exposure metric of this paper, may result in mild deficits of cognitive function in adult populations. [Description provided by NIOSH]
• Subjects:
  Air Air Pollutants, Occupational Community Health Services Environment Environmental Exposure Environmental Monitoring Manganese Manufacturing And Industrial Facilities Mental Health Metals Metal Workers Nervous System Nervous System Diseases Occupational Health Pathology Respiratory System Safety

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• Keywords:
  Airborne Particles Air Monitoring Analytical Processes Author Keywords: Manganese Brain Function Chemical Industry Workers Cognitive Function Community Health Cross Sectional Studies Environmental Environmental Exposure Exposure Assessment Humans Industrial Processes Inhalation Neurological Disorders Neurological System Neurophysiological Effects Neuropsychology Psychological Effects Smelters Visual Motor Performance

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• ISSN:
  0161-813X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; Illinois ; North Carolina ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  139-148
• Volume:
  49
• NIOSHTIC Number:
  nn:20047937
• Citation:
  Neurotoxicology 2015 Jul; 49:139-148
• Contact Point Address:
  Rosemarie M. Bowler, 8371 Kent Drive, El Cerrito, CA 94530, USA
• Email:
  rbowl@sfsu.edu
• CAS Registry Number:
  Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2015
• Performing Organization:
  San Francisco State University
• Peer Reviewed:
  True
• Start Date:
  20080401
• Source Full Name:
  Neurotoxicology
• End Date:
  20090331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a42717cc9c190dac2f1d685bc30f5fe856918f4ee7e5c71f6345b8de7dabcc2b61a5d2c53d050bd5b543008959216bfaeb1dde0543735656f3c07cf4db2f8c2c
• Download URL:
  https://stacks.cdc.gov/view/cdc/202869/cdc_202869_DS1.pdf
• File Type:
  [PDF - 426.58 KB ]