Head injury at early ages is associated with risk of Parkinson's disease

Details

• Personal Author:
  Hersh B ; Hu H ; Saint-Hilaire M-H ; Simon DK ; Sparrow D ; Sudarsky L ; Taylor KM ; Weisskopf MG
• Description:
  Introduction: The literature on the effect of head injuries on the risk of PD is inconclusive. Some researchers have hypothesized that studies that have seen an effect are simply capturing injury related to pre-clinical PD. However in animal models brain inflammation, which can be initiated by head trauma, has been shown to produce PD-like effects. Furthermore, animal studies have found that early life inflammation in particular is of relevance for PD pathology. Methods: We conducted an unmatched case-control study of 379 neurologist confirmed PD patients and 230 controls from the greater Boston, Massachusetts area with questionnaire data on history of head injury and other covariates. We used multivariable logistic regression to estimate adjusted odds ratios (OR) and their corresponding 95% confidence intervals (CI) for PD. Results: When we excluded injuries that occurred less than 10 years prior to the diagnosis of PD (in order to avoid reverse causation), we found an increased risk of PD associated with a head injury that resulted in a loss of consciousness, but it did not reach statistical significance (OR = 1.57; 95% CI = 0.89-2.80).We found a significant (p = 0.04) effect of age at first head injury. For every 5 year earlier age at first head injury with loss of consciousness the OR for PD was 1.37 (95% CI: 1.01-1.86). Conclusion: Our results suggest that head injury in early life increases the risk of PD. [Description provided by NIOSH]
• Subjects:
  Age Factors Immune System Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety Surveys And Questionnaires
• Keywords:
  Age Factors Author Keywords: Head Injury Brain Damage Brain Function Brain Matter Head Injuries Health Surveys Immune Reaction Injuries Mathematical Models Neurological Disorders Neuromotor Activity Neuromotor Disorders Parkinson's Disease Parkinsonism Parkinsons Disease Questionnaires Risk Factors TBI Traumatic Brain Injury

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• ISSN:
  1353-8020
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  57-61
• Volume:
  23
• NIOSHTIC Number:
  nn:20047858
• Citation:
  Parkinsonism Relat Disord. 2016 Feb; 23:57-61
• Contact Point Address:
  Kathryn M. Taylor, Harvard T.H. Chan School of Public Health, Department of Environmental Health, 401 Park Dr., Landmark Building, 3rd Floor, Boston, MA 02215, USA
• Email:
  kmt691@mail.harvard.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Parkinsonism & Related Disorders
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f3dd77fa5efb3fc95fa65e80b6a23c26c5c374ff9c0fa0977aba1c354e02ab359440aeb4743931a08a58850bbb0cfdc615175c777099c6de7b1975d46822f850
• Download URL:
  https://stacks.cdc.gov/view/cdc/202817/cdc_202817_DS1.pdf
• File Type:
  [PDF - 297.99 KB ]