A Projectile Concussive Impact Model Produces Neuroinflammation in Both Mild and Moderate-Severe Traumatic Brain Injury (Dataset)

Details

• Personal Author:
  Kelly KA ; Michalovicz LT ; O'Callaghan JP
• Description:
  Traumatic brain injury (TBI) is as a major cause of death and disability experienced by nearly 3 million people annually resulting from falls, vehicular accidents, or from being struck by or against an object. While TBIs can range in severity, the majority of injuries are considered to be mild. However, TBI of any severity has the potential to have long-lasting neurological effects including headaches, cognitive/memory impairments, mood dysfunction, and fatigue as a result of neuronal damage and neuroinflammation. The goal of the study was to evaluate the neuroinflammatory and neuronal damage outcomes associated with mild or moderate-severe TBI via the modification of an established closed-head injury model of TBI by varying the material of the projectile. Rats that received TBI using a stainless steel projectile exhibited outcomes strongly correlated to moderate-severe TBI, such as prolonged unconsciousness, impaired neurobehavior, increased risk for hematoma and death, as well as significant neuronal degeneration and neuroinflammation throughout the cortex, hippocampus, thalamus, and cerebellum. In contrast, rats that received TBI with an aluminum projectile exhibited characteristics more congruous with mild TBI, such as a trend for longer periods of unconscious in the absence of neurobehavioral deficits, a lack of neurodegeneration and mild neuroinflammation. Our results indicate that different levels of behavioral, neuroinflammatory, and damage outcomes are associated with differing levels of TBI severity. [Description provided by NIOSH]
• Subjects:
  Animals Behavior Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Animal Studies Brain Matter Cognitive Function Head Injuries Neurological Disorders TBI Traumatic Brain Injury
• DOI:
  https://doi.org/10.26616/NIOSHRD-1066-2023-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20067478
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1066-2023-0, 2023 May; :dataset
• Contact Point Address:
  NIOSH/HELD Toxicology and Molecular Biology Branch. Tel: 304.285.6272
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Transportation, Warehousing and Utilities
• Peer Reviewed:
  False
• Source Full Name:
  A projectile concussive impact model produces neuroinflammation in both mild and moderate-severe traumatic brain injury
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7d31d87f33ef21ef8595aee135ef2f1428e7e3128afc346b50bb72ddc7ccfba0cd22009e43307689cb50d325f5695b5cf0867dc6a99b6086e51d14bc9e05ba41
• Download URL:
  https://stacks.cdc.gov/view/cdc/231470/cdc_231470_DS1.pdf
• File Type:
  [PDF - 95.73 KB ]