Epileptiform Activity in Traumatic Brain Injury Predicts Post-Traumatic Epilepsy

Details

• Personal Author:
  Boyle EJ ; Cash SS ; Cole AJ ; Kim JA ; Staley KJ ; Westover MB ; Wu AC ; Zafar S
• Description:
  We hypothesize that epileptiform abnormalities (EAs) in the electroencephalogram (EEG) during the acute period following traumatic brain injury (TBI) independently predict first-year post-traumatic epilepsy (PTE1). We analyze PTE1 risk factors in two cohorts matched for TBI severity and age (n = 50). EAs independently predict risk for PTE1 (odds ratio [OR], 3.16 [0.99, 11.68]); subdural hematoma is another independent risk factor (OR, 4.13 [1.18, 39.33]). Differences in EA rates are apparent within 5 days following TBI. Our results suggest that increased EA prevalence identifies patients at increased risk for PTE1, and that EAs acutely post-TBI can identify patients most likely to benefit from antiepileptogenesis drug trials. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Brain Damage Brain Electrical Activity Cohort Studies Neurological Disorders Risk Factors TBI Traumatic Brain Injury
• ISSN:
  0364-5134
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  83
• Issue:
  4
• NIOSHTIC Number:
  nn:20056610
• Citation:
  Ann Neurol 2018 Apr; 83(4):858-862
• Contact Point Address:
  Dr M. Brandon Westover, Department of Neurology, Massachusetts General Hospital, 15 Parkman Street, Wang ACC 739 L, Boston, MA 02114
• Email:
  mwestover@mgh.harvard.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of Neurology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c7def970537399d7735cdee8ffc8f24a683830f15a6d1619c859a4855ca71f83080af8092dbecd386e03bfa3e5aa113e9421b9f7263c3285f6d8aa794b917773
• Download URL:
  https://stacks.cdc.gov/view/cdc/214184/cdc_214184_DS1.pdf
• File Type:
  [PDF - 270.45 KB ]