Polybrominated diphenyl ethers (PBDE) and their hydroxlyated and methoxylated derivatives in blood from e-waste recyclers, commercial fisherman and office workers in the Puget Sound, Washington Region

Details

• Personal Author:
  Cade S ; Kuo L-J ; Schultz I
• Description:
  Synthetic polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants in many consumer products including electronic devices. Important routes of human exposure are contaminated food and contact with dust found in households and workplaces. Structurally related derivatives of PBDEs are the hydroxylated (OHPBDEs) and methoxylated forms (MeO-PBDEs). Humans can metabolize some PBDEs into the OH-PBDE derivative, which is a concern due to greater health risks associated with OH-PBDEs. However, certain OHPBDEs and MeO-PBDEs are also marine natural products and it is unclear although likely, that marine fish and shellfish, which bioaccumulate these compounds serve as a vector for human exposures. In this study, we compared approximately 30 different PBDE, OH-PBDEs and MeOPBDEs in household / workplace dust and blood plasma samples provided by 114 volunteers living in the Puget Sound region of Washington State and working in the commercial fishing, electronic recycling (E-waste) or non-specific office occupations. Prior to blood sampling, a two-week food consumption diary is obtained from each volunteer. Results indicate the sum PBDE levels varied between < 30 and up to 3000 ng/ml ww. The OH-PBDEs were detected in all volunteers varying between < 5 - 800 ng/ml ww. The MeO-PBDEs were detected in most, but not all volunteers varying between 0 - 1000 ng/ml ww. For the large majority of volunteers, the sum PBDE levels exceeded the combined OH-PBDE and MeO-PBDEs. Exceptions to this observation were individuals that consumed the highest amounts of seafood (more than 5 and up to 18 servings / week). Electronic waste recyclers generally consumed low amounts of seafood and had PBDE, OH-PBDE and MeO-PBDE blood levels that were intermediate between seafood consumers and non-Ewaste office workers. Dust samples from E-waste sites were particularly enriched with PBDE-209 and PBDE-153 relative to non-E-waste businesses and homes. Initial plasma analysis for PBDE-209 suggest levels are near background and not different among occupations. [Description provided by NIOSH]
• Subjects:
  Blood Dust Electrical Equipment And Supplies Environmental Exposure Environmental Pollution Hematologic Tests Hunting Occupational Health Recycling Safety Toxicology

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• Keywords:
  Bioaccumulation Biological Effects Blood Plasma Blood Samples Contaminated-food Dust-exposure Dusts Dust Sampling Electronic Equipment Environmental Contamination Environmental Exposure Exposure Assessment Exposure Levels Fishing-industry Flame Retardants Food Humans Hydroxylation Reactions Metabolic Activation Office Workers Polybrominated Diphenyl Ethers Sampling Waste Treatment

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Louisiana ; OSHA Region 10 ; OSHA Region 6 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  150
• Issue:
  1
• NIOSHTIC Number:
  nn:20047814
• Citation:
  Toxicologist 2016 Mar; 150(1):564
• Federal Fiscal Year:
  2016
• Performing Organization:
  Battelle Pacific Northwest Laboratories
• Peer Reviewed:
  False
• Start Date:
  20130901
• Source Full Name:
  The Toxicologist. Society of Toxicology 55th Annual Meeting and ToxExpo, March 13-17, 2016, New Orleans, Louisiana
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:65145b4ddc56a51fe21dd5f8bf0aa48bb08513b0fdb420d4eab8c11a117c332a47712bafc84be0a0ffd170da7ad98066bd5d9208f2b867c0721187a387bdcdc6
• Download URL:
  https://stacks.cdc.gov/view/cdc/202785/cdc_202785_DS1.pdf
• File Type:
  [PDF - 442.32 KB ]