Polybrominated diphenyl ethers (PBDE) and their hydroxlyated and methoxylated derivatives in blood from e-waste

Details

• Personal Author:
  Kuo L ; Schultz I
• Description:
  The most important routes of human exposure to PBDEs are from contaminated food and contact with dust found in households and workplaces. Structurally related derivatives of PBDEs are the hydroxylated (OH-PBDEs) and methoxylated forms (MeO-PBDEs). Humans can metabolize some PBDEs into the hydroxylated forms, which is a concern due to greater health risks associated with OH-PBDEs. However, certain OH-PBDEs and MeO-PBDEs are also marine natural products and it is unclear although likely, that marine fish and shellfish, which bioaccumulate these compounds serve as a vector for human exposures. In this study, we are measuring approximately 50 different PBDE, OH-PBDEs and MeO-PBDEs in household / workplace dust and blood plasma samples provided by volunteers living in the Puget Sound region of Washington State and working in the commercial fishing, electronic recycling or non-specific office occupations. Prior to blood sampling, a two-week food consumption diary is obtained from each volunteer. The commercial fishing occupation is largely an outdoor activity that promotes above average seafood consumption while electronic recycling may expose workers to dust with higher than average levels of PBDEs. Results from analysis of 60 plasma samples (1/2 of the planned 120 volunteer enrollment) indicate the sum PBDE levels varied between 23 and 2740 ng/ml ww. The OH-PBDE and MeOPBDE levels varied between 5 - 706 ng/ml ww and 0 - 930 ng/ml respectively. For 90% of the volunteers, the sum PBDE levels were greater than either the OH-PBDE and MeO-PBDEs. However, a few individuals had either OH-PBDE and/or MeO-PBDE levels that exceeded the sum PBDE concentrations. These individuals tended to have consumed the highest amounts of seafood (more than 5 and up to 18 servings/week). Electronic waste recyclers generally consumed low amounts of seafood and had PBDE, OH-PBDE and MeO-PBDE blood levels that were below average. [Description provided by NIOSH]
• Subjects:
  Blood Dust Electrical Equipment And Supplies Environmental Exposure Ether Hazardous Substances Hematologic Tests Hunting Occupational Health Safety Toxicology Waste Management

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• Keywords:
  Author Keywords: Occupational Blood-plasma Blood-samples Brominated-compounds Contaminants Contaminated-food Dust-exposure Dusts Electronic-devices Emerging Environmental-exposure Ethers Fishing-industry Hazardous-materials Humans Office-workers Phenyls Waste-disposal

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; OSHA Region 10 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  144
• Issue:
  1
• NIOSHTIC Number:
  nn:20046047
• Citation:
  Toxicologist 2015 Mar; 144(1)(Abstract Suppl):182
• Federal Fiscal Year:
  2015
• Performing Organization:
  Battelle Pacific Northwest Laboratories
• Peer Reviewed:
  False
• Start Date:
  20130901
• Source Full Name:
  The Toxicologist. Society of Toxicology 54th Annual Meeting and ToxExpo, March 22-26, 2015, San Diego, California
• Supplement:
  Abstract Suppl
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4fc5217dc8e3c2e3a945921e1ec6202015fffd4ec2cc038de159d98a813e007769d895dd5ef505ffd53ead1a8a7d0bf3d7d70e0842c3fbe5f7c92e35a47da0da
• Download URL:
  https://stacks.cdc.gov/view/cdc/201231/cdc_201231_DS1.pdf
• File Type:
  [PDF - 3.17 MB ]