Exposure to respirable biodiesel/diesel blend (BD50) exhaust particulate generates pronounced aberrations in male reproductive system

Details

• Personal Author:
  Bugarski, Aleksandar D. ; Farcas MT ; Gutkin DW ; Kagan VE ; Kisin ER ; Shurin MR ; Shvedova AA ; Yanamala N
• Description:
  Biodiesel (BD) is considered an environmentally friendly, renewable fuel produced from vegetable and seed oils, animal fats and/or waste oils. Blends of BD with conventional hydrocarbon-based petroleum diesel (PD) are most commonly distributed for use in the fuel marketplace. Exposure to particles found in diesel exhaust (DE) has been reported to cause respiratory disease, cardiovascular disease and lung cancer. The disruption of male reproductive function has also been observed after exposure to DE particulates. To address whether respirable BD influences the murine male reproductive system, we compared the adverse effects of BD50 and PD exhaust particulate in C57BL6 mice. We found that pulmonary exposure to BD50 particulate significantly altered sperm integrity including concentration, motility and morphological abnormalities during the time course of post exposure. Moreover, BD50 caused up-regulation of inflammatory cytokines, increase in testicular testosterone, and reduction of serum luteinizing hormone. Testicular histopathology revealed interstitial edema, clustering of the dystrophic seminiferous tubules with arrested spermatogenesis and the presence of degenerating spermatocytes. Additionally, we observed that exposure to inhalable BD50 particulate caused severe oxidative stress and DNA damage in male reproductive organs as compared to PD. Overall, these results demonstrate that exposure to respirable BD50 exhaust particulate, in comparison to PD, generates pronounced adverse effects on male reproductive function. [Description provided by NIOSH]
• Subjects:
  Fuel Oils Hydrocarbons Immune System Laboratories Occupational Health Petroleum Safety Sex Characteristics Spermatogenesis Toxicology Urogenital Diseases Urogenital System Vehicle Emissions

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• Keywords:
  Biodiesel Cellular Uptake Cytokines Diesel Emissions Diesel Exhaust DNA Damage Exposure Assessment Fuels Gender Factors Gene Regulation Histopathology Hormone Activity Immune Reaction Laboratory Animals Laboratory Testing Morphology Organs Oxidative Stress Reproductive Effects Reproductive System Disorders Sex Factors Testes

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Louisiana ; OSHA Region 3 ; OSHA Region 6 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  150
• Issue:
  1
• NIOSHTIC Number:
  nn:20047723
• Citation:
  Toxicologist 2016 Mar; 150(1):424
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 55th Annual Meeting and ToxExpo, March 13-17, 2016, New Orleans, Louisiana
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c3b193f2c72c263d1c31baaac17db8f765ffbb822198f8091eb33b6b4cc78bb35cc1c355927c7b334498bad077fed835f9c7afd76737bc56cfb7046356629dc7
• Download URL:
  https://stacks.cdc.gov/view/cdc/202720/cdc_202720_DS1.pdf
• File Type:
  [PDF - 442.32 KB ]