Evaluation of the effect of valence state on cerium oxide nanoparticle toxicity following intratracheal instillation in rats

Details

• Personal Author:
  Badding MA ; Barger M ; Dunnick KM ; Leonard, Stephen S. ; Morris AM ; Sabolsky EM ; Stefaniak, Aleksandr B.
• Description:
  Cerium (Ce) is becoming a popular metal for use in electrochemical applications. When in the form of cerium oxide (CeO2), Ce can exist in both a 3+ and 4+ valence state, acting as an ideal catalyst. Previous in vitro and in vivo evidence have demonstrated that CeO2 has either anti- or pro-oxidant properties, possibly due to the ability of the nanoparticles to transition between valence states. Therefore, we chose to chemically modify the nanoparticles to shift the valence state toward 3+. During the hydrothermal synthesis process, 10 mol% gadolinium (Gd) and 20 mol% Gd, was substituted into the lattice of the CeO2 nanoparticles forming a perfect solid solution with various A-site valence states. These two Gd-doped CeO2 nanoparticles were compared to pure CeO2 nanoparticles. Preliminary characteristics indicated that doping results in minimal size and zeta potential changes but alters valence state. Following characterization, male Sprague-Dawley rats were exposed to 0.5 or 1.0 mg/kg nanoparticles via a single intratracheal instillation. Animals were sacrificed and bronchoalveolar lavage fluid and various tissues were collected to determine the effect of valence state and oxygen vacancies on toxicity 1, 7, or 84 days post-exposure. Results indicate that damage, as measured by elevations in lactate dehydrogenase, occurred within 1 day post-exposure and was sustained 7 days post-exposure, but subsided to control levels 84 days post-exposure. Further, no inflammatory signaling or lipid peroxidation occurred following exposure with any of the nanoparticles. Our results implicate that valence state has a minimal effect on CeO2 nanoparticle toxicity in vivo. [Description provided by NIOSH]
• Subjects:
  Animals Chemistry Laboratories Metals Occupational Health Safety
• Keywords:
  Author Keywords: Cerium Oxide Cerium Compounds Cerium Oxides Chemical Properties Chemical Reactions Intratracheal Instillation In Vitro Study In Vivo Study Laboratory Animals Metal Compounds Metallic Compounds Nanoparticles Nanotechnology Nanotoxicity Valence State

  More +
• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  10
• Issue:
  7
• NIOSHTIC Number:
  nn:20047664
• Citation:
  Nanotoxicology 2016 Sep; 10(7):992-1000
• Contact Point Address:
  Katherine Dunnick, NIOSH, HELD, PPRB 1095 Willowdale Rd Morgantown, WV 26505
• Email:
  kdunnick@mix.wvu.edu
• CAS Registry Number:
  Ceria (CAS RN 1306-38-3) ; Cerium (CAS RN 7440-45-1)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:32fb66db93f49e8973e6e819e1813685d60d8e2ba3d8d292e283c78a9af81b36198c00deadfdb73ece25233f515ca8466967459679d39a78eea34d06b4eadf4b
• Download URL:
  https://stacks.cdc.gov/view/cdc/202673/cdc_202673_DS1.pdf
• File Type:
  [PDF - 1.44 MB ]