Intratracheal instillation of nanoceria induce systemic toxicity in rats

Details

• Personal Author:
  Blough E ; Kolli M ; Ma J ; Nalabotu-Siva k ; Triest W ; Wehner P
• Description:
  Nanotechnology is a broad interdisciplinary field that is centered on the use of materials that range in size from 1-100 nm. The extensive use of nanomaterials in various sectors such as electronics, consumer goods, transportation and health industries poses an increased risk of exposure to both humans and the environment. Cerium oxide nano particles are shown to scavenge reactive oxygen species thereby they are proposed to use for the treatment of cardiovascular disease, neuronal injury and radiation induced damage. However, the systemic toxicity after cerium oxide nanoparticles exposure is not well understood. Herein, we investigate if intratracheal instillation of nanoceria is associated with alterations in blood biochemistry and histopathology of liver, kidney, spleen, and heart. Compared to control animals, cerium oxide instillation increased serum ALT levels [Saline control: 58.29 +/- 10.73 vs. CeO2 7.0 mg/kg: 130.50 +/- 94.46; p< 0.05], reduced albumin levels [Control 4.17 +/- 0.17 vs. CeO2 7.0 mg/kg 3.54 +/- 1.14] and diminished the sodium-potassium ratio [Control: 25.78 +/- 1.98 vs. CeO2 7.0mg/kg: 22.78 +/- 2.54; p< 0.05]. An analysis of the blood lipid profile indicated a reduction in the triglyceride levels [Control: 142.86 +/- 53.0 vs. CeO2 7.0 mg/kg: 93.14 +/- 22.33; p< 0.05]. Compared to control animals, animals exposed to cerium oxide exhibited a reduction in liver weight [Control: 14.55 +/- 0.57 vs. CeO2 7.0 mg/kg: 12.50 +/- 0.54; p< 0.05] and dose dependent alterations (hydropic degeneration, enlargement of the hepatocytes, sinusoidal dilatation and the accumulation of granular bodies) in liver histology. No gross histopathological alterations were observed in the kidney, spleen and heart. Taken together, these data suggest that cerium oxide nanoparticles may exit the lung after deposition producing toxicological effects in the liver. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: Cerium Oxide Nanoparticle Toxicity Cerium Oxides Laboratory Animals Nanomaterials Nanoparticles Nanotechnology
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20049412
• Citation:
  Toxicologist 2011 Mar; 120(Suppl 2)(Abstract Suppl):2784
• CAS Registry Number:
  Ceria (CAS RN 1306-38-3)
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 50th Annual Meeting and ToxExpo, March 6-10, 2011, Washington, DC
• Supplement:
  (Suppl 2)Abstract Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9067d04aaac35438cd40e5342172ff2f513ba69f7d1a2ce6642902d77aa51c8eb4f0b44a5fdc41035f7cab635eb260736c35a06fdf4d387e5b8fc10b87600cff
• Download URL:
  https://stacks.cdc.gov/view/cdc/203862/cdc_203862_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]